Results 141 to 150 of about 104,929 (312)

Cytosolic ribosomes on the surface of mitochondria

, 2017
By electron cryo-tomography and subtomogram averaging, translation-arrested ribosomes were used to depict the clustered organisation of the TOM complex on the surface of mitochondria, corroborating earlier reports of localized translation. Ribosomes were
Piotr Bragoszewski, Agnieszka Chacinska, Piotr Chroscicki, Vicki A. M. Gold   +3 more
core   +1 more source

It’s a competitive business

eLife
A new in vitro system called Rec-Seq sheds light on how mRNA molecules compete for the machinery that translates their genetic sequence into proteins.
Masaaki Sokabe, Christopher S Fraser
doaj   +1 more source

Use of the “Ru‐1O2‐Hydrazide” System Catalyzed by Metallic Ruthenium Complexes to Decipher the Interaction Between Microbes and Host Cancer Cells

Advanced Science, EarlyView.
ABSTRACT The dynamic interplay between bacteria and host cancer cells plays a critical role in tumor microenvironment modulation, bacterial pathogenesis, and potential oncotherapy applications. However, traditional methods often fail to capture transient or spatially restricted molecular interactions at the bacteria‐cancer cell interface.
Amin Sun, Kaihong Wang, Haifu Sun, Kemei Tao, Xiang Li, Xiuhua Zhao, Shuang Qiu   +6 more
wiley   +1 more source

[35] Isolation of plastid ribosomes from Euglena

, 1979
The chapter discusses the isolation of plasmid ribosomes from Euglena. The chloroplastic ribosomes of Euglena are unstable; if exposed to suboptimal ionic conditions, the 68 S monosome is converted to a 53 S particle.
Lanny I. Hecker, Schiff, Jerome A., Jerome A. Schiff, W. Edgar Barnett, Schwartzbach, S. D., Hecker, Lanny I., S.D. Schwartzbach, G. Freyssinet, Freyssinet, G.   +8 more
core   +1 more source

Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate

eLife
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ...
Mina O Seedhom, Devin Dersh, Jaroslav Holly, Mariana Pavon-Eternod, Jiajie Wei, Matthew Angel, Lucas Shores, Alexandre David, Jefferson Santos, Heather Hickman, Jonathan W Yewdell   +10 more
doaj   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

A study of ribosomes during embryonic development of Xenopus laevis

, 1965
The ribosomes of Xenopus laevis were studied during embryonic development. The RNA of the ribosomal fraction constituted only 20% of the total RNA. Approx. 70% of the total RNA of eggs is found in the first sediment of centrifugation.
Cape, Marianne, Decroly, Marc
core   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

ATPase strongly bound to higher eukaryotic ribosomes.

, 1994
80 S ribosomes from a number of higher eukaryotic organisms are able to hydrolyse ATP and GTP without the addition of soluble protein factors. ATPase seems to be an intrinsic activity of the ribosome, as indicated by the findings that ATPase activity is ...
Rodnina, M. V., El'skaya, A. V., Elskaya, A. V., Serebryanik, A. I., Rodnina, Marina, Ovcharenko, G. V.   +5 more
core   +1 more source