Results 151 to 160 of about 184,288 (339)

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Point-Wise Ribosome Translation Speed Prediction with Recurrent Neural Networks

Mathematics
Escherichia coli is a benchmark organism, which has been deeply studied by the scientific community for decades, obtaining a vast amount of metabolic and genetic data.
Pietro Bongini, Niccolò Pancino, Veronica Lachi, Caterina Graziani, Giorgia Giacomini, Paolo Andreini, Monica Bianchini   +6 more
doaj   +1 more source

CYTOPLASMIC BODIES CONTAINING MITOCHONDRIA, RIBOSOMES, AND ROUGH SURFACED ENDOPLASMIC MEMBRANES IN THE EPITHELIUM OF THE SMALL INTESTINE OF NEWBORN RATS [PDF]

, 1962
H. Moe, O. Behnke
openalex   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

It’s a competitive business

eLife
A new in vitro system called Rec-Seq sheds light on how mRNA molecules compete for the machinery that translates their genetic sequence into proteins.
Masaaki Sokabe, Christopher S Fraser
doaj   +1 more source

Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes

, 1969
Sidney Pestka
openalex   +1 more source

Lincomycin, an inhibitor of aminoacyl sRNA binding to ribosomes. [PDF]

, 1966
F.N. Chang, Charles J. Sih, Bernard Weisblum   +2 more
openalex   +1 more source

Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells

Advanced Science, EarlyView.
Nanoparticles are used to improve immunomodulatory therapies, but the impact of drug‐free nanomaterials on the immune system remains unknown. Screening common biomedical nanoparticles (NPs) reveals that PLGA NPs enhanced NK cell anti‐tumoral activity and transcriptional activation in human NK and pan T cells.
Vincent Mittelheisser, Olivier Lefebvre, Mainak Banerjee, Shayamita Ghosh, Amandine Dupas, Marie‐Charlotte Diringer, Juliette Blumberger, Louis Bochler, Sébastien Harlepp, Annabel Larnicol, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Chloé Moritz, Christine Carapito, Raphaël Carapito, Loïc J. Charbonnière, François Lux, Olivier Tillement, Jacky G. Goetz, Alexandre Detappe   +20 more
wiley   +1 more source

Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate

eLife
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ...
Mina O Seedhom, Devin Dersh, Jaroslav Holly, Mariana Pavon-Eternod, Jiajie Wei, Matthew Angel, Lucas Shores, Alexandre David, Jefferson Santos, Heather Hickman, Jonathan W Yewdell   +10 more
doaj   +1 more source

Microfluidic Biochip‐Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis

Advanced Science, EarlyView.
This study develops a diagnostic platform for early detection of esophageal squamous cell carcinoma (ESCC) by integrating a barcode immunoassay biochip with machine learning. The biochip captures and analyzes small extracellular vesicle proteins from serum samples, identifying nine biomarkers linked to ESCC.
Xue Zhang, Yibin Jia, Zhikai Li, Yunhong Zhang, Chao Wang, Yanbo Liang, Jiaoyan Qiu, Mingyuan Sun, Xiaoshuang Chen, Miao Huang, Yu Zhang, Jianbo Wang, Hong Liu, Chuanbin Mao, Lin Han   +14 more
wiley   +1 more source