Results 161 to 170 of about 254,640 (401)
Advanced Science, EarlyView.This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li +8 more
wiley +1 more source
Regulation of Protein Synthesis at the Translational Level: Novel Findings in Cardiovascular Biology
BiomoleculesTranslational regulation plays a pivotal role in cardiac gene expression, influencing protein synthesis in response to physiological and pathological stimuli.
Sergey Tsoy, Jiandong Liu
doaj +1 more source
BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43
Advanced Science, EarlyView.This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan +13 more
wiley +1 more source
Genome concentration limits cell growth and modulates proteome composition in Escherichia coli
eLifeDefining the cellular factors that drive growth rate and proteome composition is essential for understanding and manipulating cellular systems. In bacteria, ribosome concentration is known to be a constraining factor of cell growth rate, while gene ...
Jarno Mäkelä +8 more
doaj +1 more source
Advanced Science, EarlyView.Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication‐acquired, pathogen‐induced lncRNA, promotes protein N‐terminal acetylation through its interaction with NatA complex. Knockout of RESIS increases translation and confers broad‐spectrum resistance to both fungal and bacterial ...
Wen‐long Zhao +17 more
wiley +1 more source
Enzymatic Degradation of Ribosomes During Endogenous Respiration ofPseudomonas aeruginosa [PDF]
, 1965 Audrey F. Gronlund, J. J. R. Campbell
openalex +1 more source
Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells
Advanced Science, EarlyView.Nanoparticles are used to improve immunomodulatory therapies, but the impact of drug‐free nanomaterials on the immune system remains unknown. Screening common biomedical nanoparticles (NPs) reveals that PLGA NPs enhanced NK cell anti‐tumoral activity and transcriptional activation in human NK and pan T cells.
Vincent Mittelheisser +20 more
wiley +1 more source
Point-Wise Ribosome Translation Speed Prediction with Recurrent Neural Networks
MathematicsEscherichia coli is a benchmark organism, which has been deeply studied by the scientific community for decades, obtaining a vast amount of metabolic and genetic data.
Pietro Bongini +6 more
doaj +1 more source