Results 161 to 170 of about 105,196 (322)

Potential New Expression Biomarkers for Anorexia Nervosa

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Anorexia nervosa (AN) is a psychiatric disorder with an estimated heritability of around 70%. Although the largest meta‐analysis of genome‐wide association studies on AN identified independent risk‐conferring loci for the disorder, the molecular mechanisms underlying the genetic basis of AN remain to be elucidated.
Camille Verebi   +8 more
wiley   +1 more source

Chemische Proteomik enthüllt menschliche Off‐Targets der durch Fluorchinolone induzierten mitochondrialen Toxizität

open access: yesAngewandte Chemie, EarlyView.
Ein schematischer Überblick über die schädlichen Wirkungen von Ciprofloxacin im Zusammenhang mit mitochondrialer Toxizität. AIFM1 spielt eine Rolle beim MIA40‐vermittelten Import in das IMS und bei der oxidativen Faltung von kernkodierten Proteinen, einschließlich der Untereinheiten der ETC‐Komplexe I und IV.
Till Reinhardt   +14 more
wiley   +1 more source

Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

open access: yesAngewandte Chemie International Edition, EarlyView.
A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt   +14 more
wiley   +1 more source

Development of a Novel Double‐Layered Wound Dressing Composed of Chitosan Film and Tigecycline‐Loaded Electrospun Polycaprolactone Nanofibers

open access: yesJournal of Applied Polymer Science, EarlyView.
The antibacterial double‐layered wound dressing is fabricated using chitosan (CH) film as the contact layer and tigecycline (Tig)‐loaded poly(ε‐caprolactone) (PCL) nanofibers as the top layer. The CH film has a uniform morphology, and the PCL‐Tig nanofibers show a smooth, randomly oriented, and beadless structure.
Ş. Melda Eskitoros‐Togay   +5 more
wiley   +1 more source

Three stages of nascent protein translocation through the ribosome exit tunnel [PDF]

open access: yesarXiv
All proteins in living organisms are produced in ribosomes that facilitate the translation of genetic information into a sequence of amino acid residues. During translation, the ribosome undergoes initiation, elongation, termination, and recycling. In fact, peptide bonds are formed only during the elongation phase, which comprises periodic association ...
arxiv  

The Binding of Peptidyl‐tRNA and Acylaminoacyl‐tRNA to E. coli Ribosomes [PDF]

open access: bronze, 1969
Natalia Sánchez de Groot   +2 more
openalex   +1 more source

Genomic Insights Into a Strong Biofilm‐Forming Enterococcus faecalis MTR_EFS01 Strain Isolated From a Shrimp in Bangladesh

open access: yesAnimal Research and One Health, EarlyView.
This study characterizes a multidrug‐resistant and strong biofilm‐forming Enterococcus faecalis strain obtained from a shrimp sample in Bangladesh. ABSTRACT Enterococcus faecalis is known for its ability to form strong biofilms and its role as an opportunistic pathogen. In this study, we screened and characterized a multidrug‐resistant (MDR) and strong
Md. Ashek Ullah   +4 more
wiley   +1 more source

Unraveling the regulation of pyocyanin synthesis by RsmA through MvaU and RpoS in Pseudomonas aeruginosa ID4365

open access: yesJournal of Basic Microbiology, Volume 63, Issue 1, Page 51-63, January 2023., 2023
Abstract Pyocyanin is a phenazine with redox activity produced by Pseudomonas aeruginosa that is harmful to other bacteria and eukaryotic organisms by generating reactive oxygen species. Gene regulation of pyocyanin synthesis has been addressed in the PAO1 and PA14 strains and involves the three‐quorum sensing systems Las, Rhl, and Pqs; the regulators ...
Luis F. Montelongo‐Martínez   +7 more
wiley   +1 more source

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