Results 21 to 30 of about 179,543 (360)

A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid

Microbiology Spectrum, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen that presents great health concerns. Treatment requires the use of last-line antibiotics, such as members of the oxazolidinone family, of which linezolid is the first member to ...
Laura Perlaza-Jiménez, Kher-Shing Tan, Sarah J. Piper, Rachel M. Johnson, Rebecca S. Bamert, Christopher J. Stubenrauch, Alexander Wright, David Lupton, Trevor Lithgow, Matthew J. Belousoff   +9 more
doaj   +1 more source

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

EMBO Journal, 2019
The essential cellular process of ribosome biogenesis is at the nexus of various signalling pathways that coordinate protein synthesis with cellular growth and proliferation.
K. Bohnsack, M. Bohnsack
semanticscholar   +1 more source

Ribosome-omics of the human ribosome [PDF]

RNA, 2014
The torrent of RNA-seq data becoming available not only furnishes an overview of the entire transcriptome but also provides tools to focus on specific areas of interest. Our focus on the synthesis of ribosomes asked whether the abundance of mRNAs encoding ribosomal proteins (RPs) matched the equimolar need for the RPs in the assembly of ribosomes.
Gupta, Varun, Warner, Jonathan R.
openaire   +2 more sources

Crystal Structure of the 23S rRNA Fragment Specific to r-Protein L1 and Designed Model of the Ribosomal L1 Stalk from Haloarcula marismortui

Crystals, 2017
The crystal structure of the 92-nucleotide L1-specific fragment of 23S rRNA from Haloarcula marismortui (Hma) has been determined at 3.3 Å resolution.
Azat Gabdulkhakov, Svetlana Tishchenko, Alisa Mikhaylina, Maria Garber, Natalia Nevskaya, Stanislav Nikonov   +5 more
doaj   +1 more source

Modeling Cell-Free Protein Synthesis Systems—Approaches and Applications

Frontiers in Bioengineering and Biotechnology, 2020
In vitro systems are ideal setups to investigate the basic principles of biochemical reactions and subsequently the bricks of life. Cell-free protein synthesis (CFPS) systems mimic the transcription and translation processes of whole cells in a ...
Jan Müller, Martin Siemann-Herzberg, Ralf Takors   +2 more
doaj   +1 more source

The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

bioRxiv, 2019
Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a sequence of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide via the Ribosome-mediated Quality control Complex (RQC),
Karole N. D’Orazio, Colin Chih-Chien Wu, Niladri Sinha, Raphaël Loll-Krippleber, Grant W. Brown, R. Green   +5 more
semanticscholar   +1 more source

Ribosomal Proteins in Ribosome Assembly

Biomolecules
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
openaire   +4 more sources

Principles of cellular resource allocation revealed by condition-dependent proteome profiling

eLife, 2017
Growing cells coordinate protein translation with metabolic rates. Central to this coordination is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins competes with production of non-ribosomal proteins.
Eyal Metzl-Raz, Moshe Kafri, Gilad Yaakov, Ilya Soifer, Yonat Gurvich, Naama Barkai   +5 more
doaj   +1 more source

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma

Journal of Cell Biology, 1975
Fractionation of MOPC 41 DL-1 tumors revealed that the mRNA for the light chain of immunoglobulin is localized exclusively in membrane- bound ribosomes.
G. Blobel, B. Dobberstein
semanticscholar   +1 more source

Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities

Frontiers in Physiology, 2021
Skeletal muscle adaptations to resistance and endurance training include increased ribosome and mitochondrial biogenesis, respectively. Such adaptations are believed to contribute to the notable increases in hypertrophy and aerobic capacity observed with
Paulo H. C. Mesquita, Christopher G. Vann, Stuart M. Phillips, James McKendry, Kaelin C. Young, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts, Michael D. Roberts   +8 more
doaj   +1 more source