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The crystal structure of the 92-nucleotide L1-specific fragment of 23S rRNA from Haloarcula marismortui (Hma) has been determined at 3.3 Å resolution.
Azat Gabdulkhakov+5 more
doaj +1 more source
Principles of cellular resource allocation revealed by condition-dependent proteome profiling
Growing cells coordinate protein translation with metabolic rates. Central to this coordination is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins competes with production of non-ribosomal proteins.
Eyal Metzl-Raz+5 more
doaj +1 more source
The PDB and the ribosome [PDF]
This essay, which was written to commemorate the 50th anniversary of the Protein Data Bank, opens with some comments about the intentions of the scientists who pressed for its establishment and the nature of services it provides. It includes a brief account of the events that resulted in the determination of the crystal structure of the large ribosomal
openaire +3 more sources
Basic, simple and extendable kinetic model of protein synthesis
Protein synthesis is one of the most fundamental biological processes. Despite existence of multiple mathematical models of translation, surprisingly, there is no basic and simple chemical kinetic model of this process, derived directly from the detailed
Alexander N. Gorban +3 more
doaj +1 more source
Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways
Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay) and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires Hel2‐dependent uS10 ubiquitination and the RQT complex in yeast.
Ken Ikeuchi+9 more
semanticscholar +1 more source
Differential stoichiometry among core ribosomal proteins [PDF]
Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some ...
Airoldi, Edoardo+4 more
core +5 more sources
Ribosomal proteins: functions beyond the ribosome [PDF]
Although ribosomal proteins are known for playing an essential role in ribosome assembly and protein translation, their ribosome-independent functions have also been greatly appreciated. Over the past decade, more than a dozen of ribosomal proteins have been found to activate the tumor suppressor p53 pathway in response to ribosomal stress. In addition,
Peng Liao+4 more
openaire +3 more sources
Mitochondrial Translation Products before and after Integration into the Mitochondrial Membrane in Neurospora crassa [PDF]
# 1. Nascent translation products on mitochondrial ribosomes were selectively labeled in vivo in the presence of cycloheximide with radioactive leucine. They were isolated together with the ribosomes. # 2.
Michel, Rainer, Neupert, Walter
core +1 more source
Sequence and expression of a microspore cDNA clone with homology to a ribosomal protein
A cDNA library was made to RNA from corn anthers containing developing pollen at the uninucleate microspore stage. A randomly selected clone from this library which contained an insert (531 bp) was isolated and sequenced.
Michael P. Turcich+3 more
doaj +1 more source
Bacterial ribosomes are composed of three rRNA and over 50 ribosomal protein (r-protein) molecules. r-proteins are essential for ribosome assembly and structural stability and also participate in almost all ribosome functions.
Kaspar Reier+3 more
doaj +1 more source