Results 51 to 60 of about 188,934 (259)

An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii

mBio, 2022
Antibiotic resistance among bacterial pathogens continues to pose a serious global health threat. Multidrug-resistant (MDR) strains of the Gram-negative organism Acinetobacter baumannii utilize a number of resistance determinants to evade current ...
Christopher E. Morgan, Zhemin Zhang, Robert A. Bonomo, Edward W. Yu   +3 more
doaj   +1 more source

Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript

, 2011
The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the track.
Agirrezabala, Ajeet K. Sharma, Alberts, Antal, Arava, Arava, Basu, Chou, Chou, Chowdhury, Chowdhury, Ciandrini, Debashish Chowdhury, Derrida, Frank, Garai, Gilchrist, Guo, Hager, Hager, Harrington, Hirokawa, Hopfield, Ingolia, Kolomeisky, Krug, Lakatos, Lodish, MacDonald, MacDonald, Mikamo, Mukamel, Ninio, Noll, Popkov, Reynolds, Rich, Romero, Schadschneider, Schütz, Sharma, Sharma, Shaw, Shaw, Shaw, Spirin, Spirin, Thompson, Warner, Warner, Zhdanov, Zia, Zouridis   +52 more
core   +1 more source

Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase [PDF]

, 2008
In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA—U3, U14 and snR30—whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the
Bohnsack, Markus, Kos, Martin, Tollervey, David   +2 more
core   +3 more sources

How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription

Cells, 2019
The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit ...
Marco Gaviraghi, Claudia Vivori, Giovanni Tonon   +2 more
doaj   +1 more source

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Craig, Elisabeth A., Herrmann, Johannes M., Neupert, Walter, Stuart, Rosemary A.   +3 more
core   +4 more sources

Voltage Sensing in Bacterial Protein Translocation [PDF]

, 2020
The bacterial channel SecYEG efficiently translocates both hydrophobic and hydrophilic proteins across the plasma membrane. Translocating polypeptide chains may dislodge the plug, a half helix that blocks the permeation of small molecules, from its ...
Bondar, Ana-Nicoleta, Knyazev, Denis G., Kuttner, Roland, Pohl, Peter, Siligan, Christine, Zimmerman, Mirjam   +5 more
core   +1 more source

RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing

Toxins, 2022
Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan, Abbie Harrison, Hannah Trivett, Catherine Hartley, Jonathan David, Graeme C. Clark, Julian A. Hiscox   +6 more
doaj   +1 more source

Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes. [PDF]

, 1983
We located the polypeptide nascent chain as it leaves cytoplasmic ribosomes from the plant Lemna gibba by immune electron microscopy using antibodies against the small subunit of the enzyme ribulose-1,5-bisphosphate carboxylase.
Bernabeu, C, Fowler, A, Lake, JA, Tobin, EM, Zabin, I   +4 more
core  

Optimal localization patterns in bacterial protein synthesis

, 2018
In $\textit{Escherichia coli}$ bacterium, the molecular compounds involved in protein synthesis, messenger RNAs (mRNAs) and ribosomes, show marked intracellular localization patterns.
Castellana, Michele, Nguyen, Jacky
core   +4 more sources

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

eLife
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin.
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, Brianna N Smith, Macey J Slota, Elizabeth M Reynolds, Soumita Goswami, Michael R Savona, Frank M Mason, Taekyu Lee, Stephen Fesik, Qi Liu, William P Tansey   +19 more
doaj   +1 more source