Results 71 to 80 of about 105,300 (304)

The ABCs of the ribosome [PDF]

Nature Structural & Molecular Biology, 2014
An ABC protein that binds the ribosomal exit site suggests a new mechanism for direct regulation of translation in response to changing ATP levels in the cell.
Fredrick, Kurt, Ibba, Michael
openaire   +3 more sources

Bakteri ribosoomide uurimus keemilise modifitseerimise meetoditega [PDF]

, 2010
Väitekirja elektrooniline versioon ei sisalda publikatsioone.Ribosoom on suur makromolekulaarne kompleks, mis kodeerib päriliku informatsiooni valgulisse olemusse.
Pulk, Arto
core  

The space between notes: emerging roles for translationally silent ribosomes [PDF]

, 2022
In addition to their central functions in translation, ribosomes can adopt inactive structures that are fully assembled yet devoid of mRNA. We describe how the abundance of idle eukaryotic ribosomes is influenced by a broad range of biological conditions
Pandit, Sapna C, Smith, Patrick R, Loerch, Sarah, Campbell, Zachary T   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Bacterial Longevity Requires Protein Synthesis and a Stringent Response

mBio, 2019
Gram-negative bacteria in infections, biofilms, and industrial settings often stop growing due to nutrient depletion, immune responses, or environmental stresses.
Liang Yin, Hongyu Ma, Ernesto S. Nakayasu, Samuel H. Payne, David R. Morris, Caroline S. Harwood   +5 more
doaj   +1 more source

Antibiotics and the ribosome [PDF]

Molecular Microbiology, 2006
SummaryThe ribosome is one of the main antibiotic targets in the cell. Recent years brought important insights into the mode of interaction of antibiotics with the ribosome and mechanisms of antibiotic action. Ribosome crystallography provided a detailed view of the interactions between antibiotics and rRNA.
Tanel, Tenson, Alexander, Mankin
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Using Ribosomes to Create Other Polymers

, 2021
For my presentation, I am studying the use of ribosomes in the synthesis of polymers. Ribosomes are organelles that exist within living cells. Their purpose is to read messenger RNA and then form proteins based on the instructions encoded within the RNA.
St. Peter, Tyler James
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Ribosomes

, 2014
Ribosomes are fundamental components of the cell that are essential for its growth and proliferation. It is hard to imagine that such a fundamental physiological machinery, as ribosomes, does not participate in cancer biology.
Sara Ricciardi, Fabrizio Loreni, Ricciardi S, Loreni F   +3 more
core   +1 more source