Results 81 to 90 of about 104,929 (312)
Ribosomal protein paralogues in ribosome specialization
Philosophical Transactions of the Royal Society B: Biological SciencesRibosomes are macromolecular complexes responsible for protein synthesis, comprising ribosomal proteins (RPs) and ribosomal RNA. While most RPs are present as single copies in higher eukaryotes, a handful of them have paralogues that emerged through duplication events.
Ivan Milenkovic, Eva Maria Novoa
openaire +3 more sources
Advanced Functional Materials, EarlyView.An interstitium‐mimicking membrane combines three‐dimensional alveolar geometry, high pore interconnectivity, and mechanical compliance to overcome transport limitations of conventional lung‐on‐chip barriers. The resulting platform supports physiologic aerosol transport, quantitative analysis of cross‐barrier particle movement, and reveals divergent ...
Jae‐Won Choi +11 more
wiley +1 more source
A 'garbage can' for ribosomes: how eukaryotes degrade their ribosomes.
, 2010 Ribosome synthesis is a major metabolic activity that involves hundreds of individual reactions, each of which is error-prone. Ribosomal insults occur in cis (alteration in rRNA sequences) and in trans (failure to bind to, or loss of, an assembly factor ...
Lafontaine, Denis
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Advanced Science, EarlyView.Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu +12 more
wiley +1 more source
Using Ribosomes to Create Other Polymers
, 2021 For my presentation, I am studying the use of ribosomes in the synthesis of polymers. Ribosomes are organelles that exist within living cells. Their purpose is to read messenger RNA and then form proteins based on the instructions encoded within the RNA.
St. Peter, Tyler James
core
Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]
, 1994 Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
W Neupert +7 more
core +1 more source
The Arabidopsis cytosolic ribosomal proteome: from form to function
Frontiers in Plant Science, 2013 The cytosolic ribosomal proteome of Arabidopsis thaliana has been studied intensively by a range of proteomics approaches and is now one of the best-characterised eukaryotic ribosomal proteomes.
Adam James Carroll
doaj +1 more source
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Dom34 Rescues Ribosomes in 3′ Untranslated Regions
, 2014 SummaryRibosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is ...
Guydosh, Nicholas R., Green, Rachel
core +1 more source
Accelerating cancer without mutations
eLife, 2019 Mice get melanoma faster when they have common, inherited variants in a few genes that control cell-wide changes but also respond to the environment.
Douglas E Brash
doaj +1 more source