Results 41 to 50 of about 239,527 (406)
Bacterial Longevity Requires Protein Synthesis and a Stringent Response
mBio, 2019 Gram-negative bacteria in infections, biofilms, and industrial settings often stop growing due to nutrient depletion, immune responses, or environmental stresses.
Liang Yin +5 more
doaj +1 more source
Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways
EMBO Journal, 2019 Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay) and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires Hel2‐dependent uS10 ubiquitination and the RQT complex in yeast.
Ken Ikeuchi +9 more
semanticscholar +1 more source
How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription
Cells, 2019 The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit ...
Marco Gaviraghi +2 more
doaj +1 more source
Lessons in aging from Myc knockout mouse models
Frontiers in Cell and Developmental Biology, 2023 Despite MYC being among the most intensively studied oncogenes, its role in normal development has not been determined as Myc−/− mice do not survival beyond mid-gestation.
Edward V. Prochownik +4 more
doaj +1 more source
Identifying ribosome heterogeneity using ribosome profiling
Nucleic Acids Research, 2022 Abstract Recent studies have revealed multiple mechanisms that can lead to heterogeneity in ribosomal composition. This heterogeneity can lead to preferential translation of specific panels of mRNAs, and is defined in large part by the ribosomal protein (RP) content, amongst other things.
Ferhat Alkan +6 more
openaire +6 more sources
Uncovering the assembly pathway of human ribosomes and its emerging links to disease
EMBO Journal, 2019 The essential cellular process of ribosome biogenesis is at the nexus of various signalling pathways that coordinate protein synthesis with cellular growth and proliferation.
K. Bohnsack, M. Bohnsack
semanticscholar +1 more source
Antibiotics, 2023 Oxazolidinones are a broad-spectrum class of synthetic antibiotics that bind to the 50S ribosomal subunit of Gram-positive and Gram-negative bacteria.
McKenna E. Buckley +5 more
doaj +1 more source
The inhibition of ribosomal ribonuclease by bacterial ribosomes [PDF]
Biochemical Journal, 1965 1. A comparison has been made between the ribonuclease activities of untreated ribosomes from Escherichia coli B and Pseudomonas fluorescens and the activities of ribosomes on to which ribosomal ribonuclease from E. coli B has been adsorbed. 2. The normal ribosomes from both species were stable in 5-10mm-Mg(2+) (I0.16) at pH6. The RNA in ribosomes from
HE Wade, HK Robinson
openaire +3 more sources
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
bioRxiv, 2019 Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a sequence of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide via the Ribosome-mediated Quality control Complex (RQC),
Karole N. D’Orazio +5 more
semanticscholar +1 more source
Computational and Functional Analysis of Structural Features in the ZAKα Kinase
Cells, 2023 The kinase ZAKα acts as the proximal sensor of translational impairment and ribotoxic stress, which results in the activation of the MAP kinases p38 and JNK. Despite recent insights into the functions and binding partners of individual protein domains in
Valdemar Brimnes Ingemann Johansen +4 more
doaj +1 more source