Results 41 to 50 of about 184,288 (339)
Macromolecular Structure Assembly as a Novel Antibiotic Target
Antibiotics, 2022 This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target.
Scott Champney
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Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
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The Effects of Deregulated Ribosomal Biogenesis in Cancer
Biomolecules, 2023 Ribosomes are macromolecular ribonucleoprotein complexes assembled from RNA and proteins. Functional ribosomes arise from the nucleolus, require ribosomal RNA processing and the coordinated assembly of ribosomal proteins (RPs), and are frequently ...
Yiwei Lu, Shizhuo Wang, Yisheng Jiao
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The 73 S ribosome of Neurospora crassa is the native mitochondrial ribosome [PDF]
, 1977 The effect of the inclusion of EDTA and of heparin, in media used in the isolation of mitochondria, on the mitochindrial previous termribosomenext term has been investigated. 1. 1.
Adelmann +24 more
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Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging
Epigenomes, 2023 Although reported in the literature, ribosome heterogeneity is a phenomenon whose extent and implications in cell and organismal biology is not fully appreciated.
Rowshan Ara Islam, Charalampos Rallis
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Nuclear 80S Ribosomes Present Across the Stages of Cell Cycle in Drosophila Melanogaster Cells
UMYU Journal of Microbiology Research, 2023 Nuclear translation has been a subject of controversy between scientists for over 5 decades. Despite the existence of evidence to the contrary, most biologists agree that translation exclusively takes place in the cytoplasm of eukaryotes.
Akilu Abdullahi, Saverio Brogna
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Stochastic kinetics of ribosomes: single motor properties and collective behavior [PDF]
, 2009 Synthesis of protein molecules in a cell are carried out by ribosomes. A ribosome can be regarded as a molecular motor which utilizes the input chemical energy to move on a messenger RNA (mRNA) track that also serves as a template for the polymerization ...
A. S. Spirin +11 more
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Frontiers in Plant Science, 2013 Isolation of biologically active cell components from multicellular eukaryotic organisms often poses difficult challenges such as low yields and inability to retain the integrity and functionality of the purified compound. We previously identified a cap-
Vera Aleksey Stupina +1 more
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Frontiers in Cell and Developmental Biology, 2019 Mitochondria exert their many functions through a repertoire of hundreds of proteins. The vast majority of these proteins are encoded in the nuclear genome, translated in the cytosol and imported into the mitochondria. Current models, derived mainly from
Dikla Vardi-Oknin +2 more
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mBio, 2021 During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in ...
Daniel J. Bennison +5 more
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