Results 41 to 50 of about 254,640 (401)
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
bioRxiv, 2019 Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a sequence of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide via the Ribosome-mediated Quality control Complex (RQC),
Karole N. D’Orazio +5 more
semanticscholar +1 more source
The inhibition of ribosomal ribonuclease by bacterial ribosomes [PDF]
Biochemical Journal, 1965 1. A comparison has been made between the ribonuclease activities of untreated ribosomes from Escherichia coli B and Pseudomonas fluorescens and the activities of ribosomes on to which ribosomal ribonuclease from E. coli B has been adsorbed. 2. The normal ribosomes from both species were stable in 5-10mm-Mg(2+) (I0.16) at pH6. The RNA in ribosomes from
HE Wade, HK Robinson
openaire +3 more sources
Identifying ribosome heterogeneity using ribosome profiling
Nucleic Acids Research, 2022 Abstract Recent studies have revealed multiple mechanisms that can lead to heterogeneity in ribosomal composition. This heterogeneity can lead to preferential translation of specific panels of mRNAs, and is defined in large part by the ribosomal protein (RP) content, amongst other things.
Ferhat Alkan +6 more
openaire +6 more sources
Principles of cellular resource allocation revealed by condition-dependent proteome profiling
eLife, 2017 Growing cells coordinate protein translation with metabolic rates. Central to this coordination is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins competes with production of non-ribosomal proteins.
Eyal Metzl-Raz +5 more
doaj +1 more source
Modeling Cell-Free Protein Synthesis Systems—Approaches and Applications
Frontiers in Bioengineering and Biotechnology, 2020 In vitro systems are ideal setups to investigate the basic principles of biochemical reactions and subsequently the bricks of life. Cell-free protein synthesis (CFPS) systems mimic the transcription and translation processes of whole cells in a ...
Jan Müller +2 more
doaj +1 more source
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Macromolecular Structure Assembly as a Novel Antibiotic Target
Antibiotics, 2022 This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target.
Scott Champney
doaj +1 more source
Journal of Cell Biology, 1975 Fractionation of MOPC 41 DL-1 tumors revealed that the mRNA for the light chain of immunoglobulin is localized exclusively in membrane- bound ribosomes.
G. Blobel, B. Dobberstein
semanticscholar +1 more source
The Effects of Deregulated Ribosomal Biogenesis in Cancer
Biomolecules, 2023 Ribosomes are macromolecular ribonucleoprotein complexes assembled from RNA and proteins. Functional ribosomes arise from the nucleolus, require ribosomal RNA processing and the coordinated assembly of ribosomal proteins (RPs), and are frequently ...
Yiwei Lu, Shizhuo Wang, Yisheng Jiao
doaj +1 more source
Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing
bioRxiv, 2019 Translation initiation is considered overall rate-limiting for protein biosynthesis, whereas the impact of non-uniform ribosomal elongation rates is largely unknown. Using a modified ribosome profiling protocol based on footprints from two closely packed
A. B. Arpat +5 more
semanticscholar +1 more source