Macromolecular Structure Assembly as a Novel Antibiotic Target
Antibiotics, 2022 This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target.
Scott Champney
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Puromycin Sensitivity of Ribosomal Label after Incorporation of 14C-Labelled Amino Acids into Isolated Mitochondria from Neurospora crassa [PDF]
, 1969 Radioactive amino acids were incorporated into isolated mitochondria from Neurospora crassa. Then the mitochondrial ribosomes were isolated and submitted to density gradient centrifugation. A preferential labelling of polysomes was observed.
Dingman C. W. +8 more
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The Effects of Deregulated Ribosomal Biogenesis in Cancer
Biomolecules, 2023 Ribosomes are macromolecular ribonucleoprotein complexes assembled from RNA and proteins. Functional ribosomes arise from the nucleolus, require ribosomal RNA processing and the coordinated assembly of ribosomal proteins (RPs), and are frequently ...
Yiwei Lu, Shizhuo Wang, Yisheng Jiao
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Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in a Cell Free System from Neurospora crassa [PDF]
, 1977 Synthesis and transport of mitochondrial proteins were followed in a cell-free homogenate of Neurospora crassa in which mitochondrial translation was inhibited. Proteins synthesized on cytoplasmic ribosomes are transferred into the mitochondrial fraction.
Andrews T. M. +30 more
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Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging
Epigenomes, 2023 Although reported in the literature, ribosome heterogeneity is a phenomenon whose extent and implications in cell and organismal biology is not fully appreciated.
Rowshan Ara Islam, Charalampos Rallis
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Nuclear 80S Ribosomes Present Across the Stages of Cell Cycle in Drosophila Melanogaster Cells
UMYU Journal of Microbiology Research, 2023 Nuclear translation has been a subject of controversy between scientists for over 5 decades. Despite the existence of evidence to the contrary, most biologists agree that translation exclusively takes place in the cytoplasm of eukaryotes.
Akilu Abdullahi, Saverio Brogna
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Distribution of dwell times of a ribosome: effects of infidelity, kinetic proofreading and ribosome crowding [PDF]
Physical Biology, 8 (2011) 026005, 2010 Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triplets of nucleotides) on a messenger RNA (mRNA) that serves as the template. The ribosome is a molecular motor that utilizes the template mRNA strand also as the track. Thus, in
arxiv +1 more source
Growth-laws and invariants from ribosome biogenesis in lower Eukarya [PDF]
Phys. Rev. Research 3, 013020 (2021), 2020 Eukarya and Bacteria are the most evolutionarily distant domains of life, which is reflected by differences in their cellular structure and physiology. For example, Eukarya feature membrane-bound organelles such as nuclei and mitochondria, whereas Bacteria have none.
arxiv +1 more source
Osmotic regulation of alpha-amylase synthesis and polyribosome formation in aleurone cells of barley. [PDF]
, 1973 Water stress inhibits the gibberellic acid (GA(3))-induced synthesis of alpha-amylase in aleurone layers of barley (Hordeum vulgare L.). Electron microscope evidence indicates that the effect of water stress induced by 0.6 M solutions of polyethylene ...
Armstrong, J, JONES, Russell L.
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Frontiers in Plant Science, 2013 Isolation of biologically active cell components from multicellular eukaryotic organisms often poses difficult challenges such as low yields and inability to retain the integrity and functionality of the purified compound. We previously identified a cap-
Vera Aleksey Stupina +1 more
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