Results 71 to 80 of about 105,047 (174)

Ribosome collisions and Translation efficiency: Optimization by codon usage and mRNA destabilization [PDF]

open access: yesJ. Mol. Biol. 382, 236-245 (2008), 2008
Individual mRNAs are translated by multiple ribosomes that initiate translation with a few seconds interval. The ribosome speed is codon dependant, and ribosome queuing has been suggested to explain specific data for translation of some mRNAs in vivo. By modelling the stochastic translation process as a traffic problem, we here analyze conditions and ...
arxiv  

It’s a competitive business

open access: yeseLife
A new in vitro system called Rec-Seq sheds light on how mRNA molecules compete for the machinery that translates their genetic sequence into proteins.
Masaaki Sokabe, Christopher S Fraser
doaj   +1 more source

Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate

open access: yeseLife
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ...
Mina O Seedhom   +10 more
doaj   +1 more source

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