Results 81 to 90 of about 181,355 (258)

Promising Assays for Examining a Putative Role of Ribosomal Heterogeneity in COVID-19 Susceptibility and Severity

Life, 2022
The heterogeneity of ribosomes, characterized by structural variations, arises from differences in types, numbers, and/or post-translational modifications of participating ribosomal proteins (RPs), ribosomal RNAs (rRNAs) sequence variants plus post ...
Yih-Horng Shiao
doaj   +1 more source

Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes. [PDF]

, 1993
Ribosomes synthesizing nascent secretory proteins are targeted to the membrane by the signal recognition particle (SRP), a small ribonucleoprotein that binds to the signal peptide as it emerges from the ribosome.
Walter, P, Wolin, SL
core  

Spatial organization of bacterial transcription and translation

, 2016
In bacteria such as $\textit{Escherichia coli}$, DNA is compacted into a nucleoid near the cell center, while ribosomes$-$molecular complexes that translate messenger RNAs (mRNAs) into proteins$-$are mainly localized at the poles.
Castellana, Michele, Li, Sophia Hsin-Jung, Wingreen, Ned S.   +2 more
core   +1 more source

Cell-free synthesis of cytochrome c [PDF]

, 1979
Cytochrome c is a peripheral membrane protein, attached to the cytoplasmic surface of the inner mito-chondrial membrane [l-4].
Blombäck, Cassio, Chance, De Pierre, Dubnoff, Estabrook, Fisher, Gonzales-Cadavid, Hackenbrock, Hallermayer, Harmey, Heller, Korb, Lederer, Lodish, Palmiter, Richard Zimmermann, Schatz, Scheele, Sebald, Sherman, Smith, Stewart, Strauss, Ulrich Paluch, Walter Neupert, Zimmermann, Zitomer   +27 more
core   +1 more source

A limited concentration range of diaphorin, a polyketide produced by a bacterial symbiont of the Asian citrus psyllid, promotes the in vitro gene expression with bacterial ribosomes

Microbiology Spectrum
Diaphorin is a polyketide produced by “Candidatus Profftella armatura” (Gammaproteobacteria: Burkholderiales), an obligate symbiont of a devastating agricultural pest, the Asian citrus psyllid Diaphorina citri (Hemiptera: Psyllidae).
Rena Takasu, Takashi Izu, Atsushi Nakabachi   +2 more
doaj   +1 more source

RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing

Toxins, 2022
Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan, Abbie Harrison, Hannah Trivett, Catherine Hartley, Jonathan David, Graeme C. Clark, Julian A. Hiscox   +6 more
doaj   +1 more source

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

eLife
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin.
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, Brianna N Smith, Macey J Slota, Elizabeth M Reynolds, Soumita Goswami, Michael R Savona, Frank M Mason, Taekyu Lee, Stephen Fesik, Qi Liu, William P Tansey   +19 more
doaj   +1 more source

Better than Membranes at the Origin of Life?

Life, 2017
Organelles without membranes are found in all types of cells and typically contain RNA and protein. RNA and protein are the constituents of ribosomes, one of the most ancient cellular structures.
Helen Greenwood Hansma
doaj   +1 more source

Ribosome Inactivating Protein of barley enhanced resistance to Rhizoctonia solani in transgenic potato cultivar 'Desirée' in greenhouse conditions

Biotechnologie, Agronomie, Société et Environnement, 2013
In the present study, the potato cultivar 'Desirée' was transformed via Agrobacterium tumefaciens strain LBA4404 containing the plasmid pBIN19 which harbors the Ribosome Inactivating Protein (rip30).
M'hamdi, M., Chikh-Rouhou, H., Boughalleb, N., Ruiz de Galarreta, JI.   +3 more
doaj  

Identification and characterization of yeast SNF1 kinase homologs in Leishmania major

Frontiers in Molecular Biosciences
BackgroundSucrose Non Fermenting1 (SNF1) constitutes a family of protein kinases conserved in eukaryotes, plants, and fungi. SNF1 has been known to play a crucial role in stress adaptation and metabolism, enabling organisms to respond to changing ...
Gaurav Shoeran, Namrata Anand, Upninder Kaur, Kapil Goyal, Rakesh Sehgal   +4 more
doaj   +1 more source