Results 101 to 110 of about 12,203 (191)
Computational identification and analysis of noncoding RNAs - Unearthing the buried treasures in the genome [PDF]
, 2007 The central dogma of molecular biology states that the genetic information flows from DNA to RNA to protein. This dogma has exerted a substantial influence on our understanding of the genetic activities in the cells.
Vaidyanathan, P. P., Yoon, Byung-Jun
core
Structure-guided design of a high affinity ligand for a riboswitch [PDF]
, 2019 We have designed structure-based ligands for the guanidine-II riboswitch that bind with enhanced affinity, exploiting the twin binding sites created by loop–loop interaction.
Huang, Lin +3 more
core +3 more sources
Binding versus Triggering Riboswitches
Chemistry & Biology, 2014 In this issue of Chemistry & Biology, Trausch and Batey report a discrepancy between ligand binding affinity and the effect of transcription termination in a THF riboswitch, raising some important questions about our current understanding of ligand-dependent RNA switches.
openaire +3 more sources
Unexpected versatility in bacterial riboswitches [PDF]
Trends in Genetics, 2015 Bacterial riboswitches are elements present in the 5'-untranslated regions (UTRs) of mRNA molecules that bind to ligands and regulate the expression of downstream genes. Riboswitches typically regulate the expression of protein-coding genes. However, mechanisms of riboswitch-mediated regulation have recently been shown to be more diverse than ...
Mellin, J R, Cossart, Pascale
openaire +3 more sources
Advanced Science, Volume 12, Issue 41, November 6, 2025.This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang +7 more
wiley +1 more source
Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems
Aggregate, Volume 6, Issue 11, November 2025.Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo +6 more
wiley +1 more source
RNA under Tension: Folding Landscapes, Kinetic Partitioning Mechanism, and Molecular Tensegrity
, 2012 Non-coding RNA sequences play a great role in controlling a number of cellular functions, thus raising the need to understand their complex conformational dynamics in quantitative detail.
Hyeon, Changbong +2 more
core +1 more source
Small Structures, Volume 6, Issue 11, November 2025.The review comprehensively summarizes the binding behaviors and multidimensional applications of malachite green with diverse functional nucleic acids. By integrating structural mechanisms, comparative analysis, and application strategies across eight domains, it provides theoretical guidance and future perspectives for developing intelligent nucleic ...
Keren Chen +4 more
wiley +1 more source
Structural Basis for Molecular Discrimination by a 3′,3′-cGAMP Sensing Riboswitch
Cell Reports, 2015 Cyclic dinucleotides are second messengers that target the adaptor STING and stimulate the innate immune response in mammals. Besides protein receptors, there are bacterial riboswitches that selectively recognize cyclic dinucleotides.
Aiming Ren +6 more
doaj +1 more source
New Phytologist, Volume 248, Issue 4, Page 1639-1654, November 2025.Summary The physiological significance of lithium (Li+) remains largely unexplored in plants despite its consistent presence in at least trace concentrations in plant tissues. While Li+ has traditionally been associated with salinity‐like stress symptoms and presumed to utilise sodium (Na+) transport pathways, accumulating evidence points to multiple ...
Sebastian Garcia‐Daga +2 more
wiley +1 more source