Results 111 to 120 of about 28,198 (287)
A structural analysis of
BMC Bioinformatics, 2007 Background Ribozymes are small catalytic RNAs that possess the dual functions of sequence-specific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit translation of genes at the messenger RNA (mRNA) level in both eukaryotic ...
Schneider Erasmus +5 more
doaj +1 more source
Deciphering recent transposition patterns in plants through comparison of 811 genome assemblies
Plant Biotechnology Journal, Volume 23, Issue 4, Page 1121-1132, April 2025.Summary Transposable elements (TEs) are significant drivers of genome evolution, yet their recent dynamics and impacts within and among species, as well as the roles of host genes and non‐coding RNAs in the transposition process, remain elusive. With advancements in large‐scale pan‐genome sequencing and the development of open data sharing, large‐scale
Yan Huang, Sunil Kumar Sahu, Xin Liu
wiley +1 more source
Short-term sequence evolution and vertical inheritance of the
BMC Evolutionary Biology, 2006 Background Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene.
De Jonckheere Johan F +3 more
doaj +1 more source
Engineering an optimized hypercompact CRISPR/Cas12j‐8 system for efficient genome editing in plants
Plant Biotechnology Journal, Volume 23, Issue 4, Page 1153-1164, April 2025.Summary The Cas12j‐8 nuclease, derived from the type V CRISPR system, is approximately half the size of Cas9 and recognizes a 5′‐TTN‐3′ protospacer adjacent motif sequence, thus potentially having broad application in genome editing for crop improvement. However, its editing efficiency remains low in plants. In this study, we rationally engineered both
Shasha Bai +5 more
wiley +1 more source
A Cross-chiral RNA Polymerase Ribozyme
Nature, 2014 Thirty years ago it was shown that the non-enzymatic, template-directed polymerization of activated mononucleotides proceeds readily in a homochiral system, but is severely inhibited by the presence of the opposing enantiomer. This finding poses a severe
Jonathan T. Sczepanski, G. F. Joyce
semanticscholar +1 more source
Regular neutral networks outperform robust ones by reaching their top growth rate more quickly [PDF]
arXiv, 2012 We study the relative importance of "top-speed" (long-term growth rate) and "acceleration" (how quickly the long-term growth rate can be reached) in the evolutionary race to increase population size. We observe that fitness alone does not capture growth rate: robustness, a property of neutral network shape, combines with fitness to include the effect ...
arxiv
A widespread self-cleaving ribozyme class is revealed by bioinformatics
Nature Chemical Biology, 2013 Ribozymes are noncoding RNAs that promote chemical transformations with rate enhancements approaching those of protein enzymes. Although ribozymes are likely to have been abundant during the RNA world era, only ten classes are known to exist among ...
Adam Roth +5 more
semanticscholar +1 more source
JHEP Reports, 2023 Background & Aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster progression towards cirrhosis, liver decompensation, and hepatocellular carcinoma.
Eirini D. Tseligka +5 more
doaj
Plant Biotechnology Journal, EarlyView.Summary Antifungal proteins (AFPs) derived from filamentous fungi show great potential against economically significant fungi that cause plant diseases and consequently threat food safety and security. This study focuses on the Penicillium expansum PeAfpA and Penicillium digitatum PdAfpB proteins and their activity against several phytopathogens.
Adrià Bugeda +6 more
wiley +1 more source
Development and applications of Coarse Grained models for RNA [PDF]
arXiv, 2014 In contrast to proteins much less attention has been focused on development of computational models for describing RNA molecules, which are being recognized as playing key roles in many cellular functions. Current atomically detailed force fields are not accurate enough to capture the properties of even simple nucleic acid constructs.
arxiv