Results 101 to 110 of about 18,960 (170)

Oligonucleotide facilitators may inhibit or activate a hammerhead ribozyme

, 1996
Facilitators are oligonucleotides capable of affecting hammerhead ribozyme activity by interacting with the substrate at the termini of the ribozyme. Facilitator effects were determined in vitro using a system consisting of a ribozyme with 7 nucleotides ...
Bernd Schwenzer, Eckhard Jankowsky
core  

The three-dimensional architecture of the class I ligase ribozyme.

, 2004
The class I ligase ribozyme catalyzes a Mg(++)-dependent RNA-ligation reaction that is chemically analogous to a single step of RNA polymerization. Indeed, this ribozyme constitutes the catalytic domain of an accurate and general RNA polymerase ribozyme.
Bergman, Nicholas H, Bartel, David P, Lau, Nelson C, Lehnert, Valerie, Westhof, Eric   +4 more
core   +2 more sources

Fast Cleavage Kinetics of a Natural Hammerhead Ribozyme

, 2016
The hammerhead ribozyme is a small RNA motif that catalyzes the cleavage and ligation of RNA. The well-studied minimal hammerhead motif is inactive under physiological conditions and requires high Mg2+ concentrations for efficient cleavage.
Anastasia Khvorova (2708578), Marella D. Canny (531397), Elizabeth Kellogg (245426), Sumedha D. Jayasena (2708581), Fiona M. Jucker (2499127), Arthur Pardi (29632)   +5 more
core   +1 more source

The Dual-Ribozyme RNA Ladder and RNA-Calibrated ssDNA Marker System for Inexpensive RNA Size Standards. [PDF]

ACS Omega
Zhao Y, Lin J, Li M, Huang L, Xie Y, Wang J.   +5 more
europepmc   +1 more source

Structure and mechanism of HDV ribozymes revealing Lewis acid catalysis by a metal ion. [PDF]

Nat Commun
Luo Y, Chen X, Lin X, Liao W, Xiao B, Li M, Qiu Z, Wilson TJ, Miao Z, Wang J, Huang L, Lilley DMJ.   +11 more
europepmc   +1 more source

Structural and Mechanistic Analysis of the Hovlinc Ribozyme

The hovlinc ribozyme is a recently discovered self-cleaving ribozyme in human ncRNA. We determined the structure of the active ribozyme to 4.1 Å using cryo-EM and the inactive ribozyme to 3.05 Å using X-ray crystallography. Both of these methods utilized
Brink, Allison
core   +1 more source

Systematic discovery of novel ribozymes with gene silencing properties from global deep-sea RNA viromes. [PDF]

Front Microbiol
Zhang Y, Zhang X.
europepmc   +1 more source

Kinetics of hairpin ribozyme cleavage in yeast

, 2008
Hairpin ribozymes catalyze a self-cleavage reaction that provides a simple model for quantitative analyses of intracellular mechanisms of RNA catalysis.
Donahue, Christine Patricia, Fedor, Martha J.   +1 more
core  

A ribozyme ligase that requires a 3' terminal phosphate on its RNA substrate. [PDF]

Nat Commun
Biswas A, Weiss Z, Szostak JW, DasGupta S.   +3 more
europepmc   +1 more source

A GTP synthase ribozyme with increased GTP turnover. [PDF]

Proc Natl Acad Sci U S A
Han X, Pepper ZJ, Arriola JT, Müller UF.   +3 more
europepmc   +1 more source