Results 101 to 110 of about 16,956 (222)
Synthetic bPNAs as Allosteric Triggers of Hammerhead Ribozyme Catalysis
, 2019 The biochemistry and structural biology of the hammerhead ribozyme (HHR) has been well-elucidated. The secondary and tertiary structural elements that enable sugar-phosphate bond scission to be be catalyzed by this RNA are clearly understood.
Yufeng, Liang, Dennis, Bong, Jie, Mao
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Aminoacyl-tRNA Synthesis by a Resin-Immobilized Ribozyme
, 2016 We report herein a new method for the aminoacylation of tRNA, using a resin-immobilized ribozyme and the cyanomethyl ester (CME) of an amino acid substrate. The oxidized form of the ribozyme was immobilized on a hydrazine resin via covalent linkage.
Hiroshi Murakami (227877) +2 more
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Structure, mécanisme et applications du ribozyme delta
, 2005 Le virus de l'hépatite delta humaine possède un génome d'ARN circulaire simple brin de 1,7 kb. Durant sa réplication en cercle roulant, la coupure des copies multimériques en monomères est assurée par la présence de motifs autocatalytiques sur ...
Fiola, Karine
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Folding and activity of the hammerhead ribozyme.
, 2002 The hammerhead is the smallest of the nucleolytic ribozymes, that undergo backbone cleavage by a transesterification reaction in the presence of magnesium ions.
Lilley, David M. J., Hammann, Christian
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Structure and use of ribozyme to generate gRNA.
, 2016 (A) Sequence of HH ribozyme. Map of HH-gRNA. First 6 bases (grey text) of the ribozyme are complementary to the first six bases of the gRNA (red text) and cleavage occurs at the 5’ end of the gRNA (arrow). (B) Denaturing PAGE gel of IVT RNA.
Ashley Shu Mei Ng (493205) +2 more
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An Alternative Ribozyme for the RNA Hypercycle
, 2013 In the quest to forward understanding of the prebiotic world (specifically, the RNA World Hypothesis), one of the most interesting paradigms to consider is the potential for cooperative networks that may have driven molecular evolution forward.
Elkhal, Ishak
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88 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.This thesis research uses single molecule spectroscopy to study the dynamics of hairpin ribozyme---an enzymatic RNA molecule capable of cleaving phosphodiester linkage.
Tan, Elliot
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Ribozyme viral infection of Hct116 cells
, 2004 Ribozymes are being researched because of the clues they provide about evolutionary history, and the possibilities they provide as therapy against many viruses and certain types of cancer.
Church, Jessica Downey
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Structural and Mechanistic Analysis of the Hovlinc Ribozyme
The hovlinc ribozyme is a recently discovered self-cleaving ribozyme in human ncRNA. We determined the structure of the active ribozyme to 4.1 Å using cryo-EM and the inactive ribozyme to 3.05 Å using X-ray crystallography. Both of these methods utilized
Brink, Allison
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Ribozyme to Proliferating Cell Nuclear Antigen to Treat Proliferative Vitreoretinopathy
, 2020 PURPOSE. A DNA-RNA chimeric ribozyme was developed that targets the mRNA of a cell cycle regulatory protein, proliferating cell nuclear antigen (PCNA).
Peter Blackburn +9 more
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