Results 81 to 90 of about 27,058 (211)
RNA under Tension: Folding Landscapes, Kinetic Partitioning Mechanism, and Molecular Tensegrity
, 2012 Non-coding RNA sequences play a great role in controlling a number of cellular functions, thus raising the need to understand their complex conformational dynamics in quantitative detail.
Hyeon, Changbong +2 more
core +1 more source
RNA catalysis in model protocell vesicles. [PDF]
, 2005 We are engaged in a long-term effort to synthesize chemical systems capable of Darwinian evolution, based on the encapsulation of self-replicating nucleic acids in self-replicating membrane vesicles.
Chen, Irene A +2 more
core +2 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Plant viruses are recognized as rapid and effective vectors to deliver CRISPR‐Cas reaction components into plants, a strategy termed virus‐induced gene editing (VIGE). However, VIGE is limited by the host range of the viral vectors. Development of new viral vectors to target a broad range of plant species will potentially enable the delivery ...
Fernando Merwaiss +3 more
wiley +1 more source
A structural analysis of
BMC Bioinformatics, 2007 Background Ribozymes are small catalytic RNAs that possess the dual functions of sequence-specific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit translation of genes at the messenger RNA (mRNA) level in both eukaryotic ...
Schneider Erasmus +5 more
doaj +1 more source
Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley +1 more source
A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish.
PLoS GeneticsPrecise regulation of gene expression is essential to understand a wide range of biological processes. Control over gene expression can be achieved using site-directed recombinases and endonucleases whose efficiency is variable and dependent on the ...
Thomas Juan +6 more
doaj +1 more source
Phylogeny of conserved adenines in linkers of Group-I introns [PDF]
, 2009 We have analyzed the linkers in group-I introns, a characteristic region that is crucial to the folding and splicing process of the folded RNA, in seventy sequences spreading across r-RNA, t-RNA and organelle genes from various organisms including algae,
Chandrasekhar Kesavan, Natarajan Ganesan
core +1 more source
Yeast, Volume 43, Issue 3, Page 77-88, May 2026.ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias +5 more
wiley +1 more source
The structure and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme
Nature CommunicationsWe have determined the crystal structure of a pseudoknot (PK)-containing hammerhead ribozyme that closely resembles the pistol ribozyme, with essentially identical secondary structure and connectivity. The activity is more sensitive to deletion of the G8
Xuelin Zhan +6 more
doaj +1 more source
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity
The FEBS Journal, Volume 293, Issue 9, Page 2579-2598, May 2026.The SARS‐CoV‐2 nucleocapsid (N) protein is not only the specific viral RNA packaging protein, but also acts as an RNA chaperone, facilitating RNA folding. We show that it facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone.
Sabrina Babl +11 more
wiley +1 more source