Results 61 to 70 of about 16,956 (222)

Intracellular Immunization against SIVmacUtilizing a Hairpin Ribozyme

, 1996
A hairpin ribozyme targeting the 3′ LTR region (9456) of SIVmac239was cloned into a murine retroviral vector. This target sequence is conserved among various SIV, as well as most HIV-2, strains.
WONG-STAAL, FLOSSIE, KRAUS, GÜNTER, JOHNSON, PAUL, HEUSCH, MARINA   +3 more
core   +1 more source

CPEB3 is associated with human episodic memory

Frontiers in Behavioral Neuroscience, 2009
Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self ...
Christian Vogler, Christian Vogler, Klara Spalek, Klara Spalek, Amanda Aerni, Philippe Demougin, Philippe Demougin, Ariane Müller, Ariane Müller, Kim-Dung Huynh, Kim-Dung Huynh, Andreas Papassotiropoul, Andreas Papassotiropoul, Dominique J F De Quervain, Dominique J F De Quervain   +14 more
doaj   +1 more source

From Prebiotic Catalysts to Modern Applications: How Early Catalysts Inspire Today's Innovations

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Simple catalytic systems that may have operated under prebiotic conditions offer useful molecular principles for the design of modern functional materials. By examining how amino acids, peptide assemblies, and metal complexes achieve catalysis through simple chemical features, this review highlights how prebiotic chemistry can inspire new strategies ...
Omer Agazani, Meital Reches
wiley   +1 more source

Analysis of Self-Cleaving Ribozyme Transition States [PDF]

, 2019
Endonucleolytic ribozymes, non-coding RNA molecules capable of self-scission, have been studied for decades. First, because of their novel functionality, and later because their capacity to serve as paradigmatic model systems of RNA catalysis.
Weissman, Benjamin
core   +1 more source

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory

eLife
A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element-binding protein 3 (Cpeb3) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the
Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan, Marie Myszka, Liqi Tong, Luiz FM Passalacqua, Timothy Bredy, Marcelo A Wood, Andrej Luptak   +11 more
doaj   +1 more source

Evidence for the involvement of G_i2 in activation of extracellular signal-regulated kinases in hepatocytes

BMC Cell Biology, 2001
Background Activation of the extracellular signal-regulated kinases ERK1 and ERK2 in hepatocytes by prostaglandin (PG)F2α was recently found to be inhibited by pertussis toxin (PTX) suggesting a role for Gi proteins. Results Targeting the Gi2α expression
Sioud Mouldy, Christoffersen Thoralf, Melien Øyvind   +2 more
doaj   +1 more source

Efficient CRISPR‐Cas9 delivery and transgene‐free multiplex genome editing in plants using cymbidium mosaic virus‐derived vectors

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY Virus‐induced genome editing (VIGE) has become a useful method by enabling transient delivery of gene‐editing reagents; however, many viral systems face limitations in cargo size, host range, or reliance on transgenic Cas9‐expressing plants.
Ying‐Wen Huang, Chung‐Chi Hu, Yu‐Hsiu Cho, Ching‐Hsiu Tsai, Na‐Sheng Lin, Yau‐Heiu Hsu, Savithramma P. Dinesh‐Kumar   +6 more
wiley   +1 more source

Investigation of the role of LRP in multidrug resistance [PDF]

, 1998
There have been many reports linking the overexpression of the lung resistance-related protein (LRP) with cross-resistance to chemotherapeutic drugs.
Byrne, Daragh
core  

A Selected Ribozyme Catalyzing Diverse Dipeptide Synthesis

, 2002
The sequence of events by which protein, RNA, and DNA emerged during early biological evolution is one of the most profound questions regarding the origin of life.
Gottlieb, Robert L, Sun, Lele, Cui, Zhiyong, Zhang, Biliang   +3 more
core   +2 more sources

Efficient inhibition of hepatitis B virus replication by hepatitis delta virus ribozymes delivered by targeting retrovirus

Virology Journal, 2010
Background Hepatitis delta virus (HDV) ribozyme is an attractive molecular tool that can specifically recognize and catalyze the self-cleavage of the viral RNA phosphodiester backbone.
Chen Long-Hua, Qi Peng, Lu Yan-Qin, Wang Chuan-Xi, Han Jin-Xiang   +4 more
doaj   +1 more source