Results 91 to 100 of about 5,544 (121)

Role of Mg2+ in the ribozyme system [PDF]

, 1987
Recently, several kinds of catalytic activities have been identified from L-19 IVS RNA or ‘ribozyme’. In the catalytic process of ribozyme, Mg2+ is required. We investigated the role of Mg2+ by molecular orbital calculation.
Imamura, Akira, Katsuya Kanda, Toh, Hiroyuki, Kanda, Katsuya, Akira Imamura, Hiroyuki Toh   +5 more
core   +1 more source

Nucleic acid enzymes: The fusion of self-assembly and conformational computing

, 2009
Macromolecules are the predominant physical substrate sup-porting information processing in organisms. Two key characteristics—conformational dynamics and self-assembly properties—render macro-molecules unique in this context.
Zauner, K.-P., Ramlan, E. I.
core   +1 more source

A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA

Communications Biology
Ribozymes, widely found in prokaryotes and eukaryotes, target nucleic acids and can be engineered as biotechnical tools or for gene regulation or immune therapy. Among them, hammerhead is the smallest and best characterized ribozyme.
Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu   +11 more
doaj   +1 more source

Autocatalytic assembly of a chimeric aminoacyl-RNA synthetase ribozyme [PDF]

Autocatalytic reactions driving the self-assembly of biological polymers are important for the origin of life, yet few experimental examples of such reactions exist.
Todisco, Marco, Mishra, Anmol, Szostak, Jack W., Radakovic, Aleksandar   +3 more
core   +1 more source

Polyanion-Assisted Ribozyme Catalysis Inside Complex Coacervates

, 2019
Owing to their ability to encapsulate biomolecules, complex coacervates formed by associative phase separation of oppositely charged polyelectrolytes have been postulated as prebiotic nonmembranous compartments (NMCs).
Raghav R. Poudyal (6806678), Philip C. Bevilacqua, Christine D. Keating, Philip C. Bevilacqua (384871), Christine D. Keating (1272396), Raghav R. Poudyal   +5 more
core   +1 more source

Identification of ribozyme mutations that increase chloramphenicol resistance.

, 2014
A, Growth rates of E.coli cells containing different ribozyme variants, in medium containing 20 µg/mL chloramphenicol. The parent ribozyme (0 Mut), the most efficient, evolved ribozyme (12 Mut; black), and ribozyme M4 (4 Mut; green) are labeled with the ...
Gregory F. Dolan (514033), Ulrich F. Müller (343881), Karen E. Olson (514032)   +2 more
core   +1 more source

Ribozyme-Mediated Knockdown of lncRNA Gene Expression in Drosophila

Bio-Protocol
Long noncoding RNAs (lncRNAs) are increasingly understood to play important roles in cell biology, development, and disease, though the vast majority of annotated lncRNAs have yet to be functionally characterized.
Kevin Nyberg, Richard Carthew
doaj   +1 more source

Structure, mécanisme et applications du ribozyme delta

, 2005
Le virus de l'hépatite delta humaine possède un génome d'ARN circulaire simple brin de 1,7 kb. Durant sa réplication en cercle roulant, la coupure des copies multimériques en monomères est assurée par la présence de motifs autocatalytiques sur ...
Fiola, Karine
core   +1 more source

Ribozyme viral infection of Hct116 cells

, 2004
Ribozymes are being researched because of the clues they provide about evolutionary history, and the possibilities they provide as therapy against many viruses and certain types of cancer.
Church, Jessica Downey
core   +1 more source

Folding and activity of the hammerhead ribozyme.

, 2002
The hammerhead is the smallest of the nucleolytic ribozymes, that undergo backbone cleavage by a transesterification reaction in the presence of magnesium ions.
Lilley, David M. J., Hammann, Christian
core