Results 91 to 100 of about 16,956 (222)
Short-term sequence evolution and vertical inheritance of the
BMC Evolutionary Biology, 2006 Background Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene.
De Jonckheere Johan F +3 more
doaj +1 more source
A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA
Communications BiologyRibozymes, widely found in prokaryotes and eukaryotes, target nucleic acids and can be engineered as biotechnical tools or for gene regulation or immune therapy. Among them, hammerhead is the smallest and best characterized ribozyme.
Man Lu +11 more
doaj +1 more source
Role of Mg2+ in the ribozyme system
, 1987 Recently, several kinds of catalytic activities have been identified from L-19 IVS RNA or ‘ribozyme’. In the catalytic process of ribozyme, Mg2+ is required. We investigated the role of Mg2+ by molecular orbital calculation.
Imamura, Akira +5 more
core +1 more source
Ribozyme-catalysed RNA synthesis using triplet building blocks
eLife, 2018 RNA-catalyzed RNA replication is widely believed to have supported a primordial biology. However, RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs.
James Attwater +4 more
doaj +1 more source
Autocatalytic assembly of a chimeric aminoacyl-RNA synthetase ribozyme [PDF]
Autocatalytic reactions driving the self-assembly of biological polymers are important for the origin of life, yet few experimental examples of such reactions exist.
Todisco, Marco +3 more
core +1 more source
Polyanion-Assisted Ribozyme Catalysis Inside Complex Coacervates
, 2019 Owing to their ability to encapsulate biomolecules, complex coacervates formed by associative phase separation of oppositely charged polyelectrolytes have been postulated as prebiotic nonmembranous compartments (NMCs).
Raghav R. Poudyal (6806678) +5 more
core +1 more source
Intracellular ribozyme applications
, 2002 The exquisite target selectivity of trans -acting ribozymes has fostered their use as potential therapeutic agents and tools for down-regulating cellular transcripts. In living cells, free diffusion of RNAs is extremely limited, if it exists at all. Thus,
Michienzi, A +7 more
core
Identification of ribozyme mutations that increase chloramphenicol resistance.
, 2014 A, Growth rates of E.coli cells containing different ribozyme variants, in medium containing 20 µg/mL chloramphenicol. The parent ribozyme (0 Mut), the most efficient, evolved ribozyme (12 Mut; black), and ribozyme M4 (4 Mut; green) are labeled with the ...
Gregory F. Dolan (514033) +2 more
core +1 more source
GROUP I INTRON-DERIVED RIBOZYME REACTIONS
, 2005 Group I introns are catalytic RNAs capable of self-splicing out of RNA transcripts. Ribozymes derived from these group I introns are used to explore the molecular recognition properties involved in intron catalysis.
Johnson, Ashley Kirtley
core
Kinetic Mechanism of the Hairpin Ribozyme
, 1997 To investigate the relationship between RNA folding and ribozyme catalysis, we have carried out a detailed kinetic analysis of four structural derivatives of the hairpin ribozyme. Optimal and suboptimal (wild-type) substrate sequences were studied in
Banerjee, Aloke Raj +2 more
core +1 more source