Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes
, 2019 The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by ...
Kamimura, Atsushi +3 more
core +2 more sources
EMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF. [PDF]
, 2013 Understanding tumor-induced angiogenesis is a challenging problem with important consequences for the diagnosis and treatment of cancer. In this study, we define a novel function for epithelial membrane protein-2 (EMP2) in the control of angiogenesis ...
Braun, J +7 more
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Short-term sequence evolution and vertical inheritance of the
BMC Evolutionary Biology, 2006 Background Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene.
De Jonckheere Johan F +3 more
doaj +1 more source
Efficient Transgene‐Free Multiplexed Germline Editing via Viral Delivery of an Engineered TnpB
Plant Biotechnology Journal, EarlyView.
Trevor Weiss +14 more
wiley +1 more source
A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA
Communications BiologyRibozymes, widely found in prokaryotes and eukaryotes, target nucleic acids and can be engineered as biotechnical tools or for gene regulation or immune therapy. Among them, hammerhead is the smallest and best characterized ribozyme.
Man Lu +11 more
doaj +1 more source
Ribozyme-catalysed RNA synthesis using triplet building blocks
eLife, 2018 RNA-catalyzed RNA replication is widely believed to have supported a primordial biology. However, RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs.
James Attwater +4 more
doaj +1 more source
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Engels, Joachim W. (Prof. Dr.) +3 more
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Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension
, 2016 Because of the potential link between -1 programmed ribosomal frameshifting and response of a pseudoknot (PK) RNA to force, a number of single molecule pulling experiments have been performed on PKs to decipher the mechanism of programmed ribosomal ...
Denesyuk, Natalia A. +2 more
core +1 more source
BMC Evolutionary Biology, 2010 Background The great variety in sequence, length, complexity, and abundance of satellite DNA has made it difficult to ascribe any function to this genome component.
Venanzetti Federica +3 more
doaj +1 more source
Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]
, 2010 Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Noeske, Jonas +2 more
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