Results 121 to 130 of about 43,119 (293)
A structural analysis of
BMC Bioinformatics, 2007 Background Ribozymes are small catalytic RNAs that possess the dual functions of sequence-specific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit translation of genes at the messenger RNA (mRNA) level in both eukaryotic ...
Schneider Erasmus +5 more
doaj +1 more source
Journal of Separation Science, Volume 48, Issue 8, August 2025.ABSTRACT Oligonucleotides are traditionally analyzed using ion‐pair reversed‐phase liquid chromatography. In this project, we explored an alternative approach utilizing a reversed phase‐weak anion exchange mixed‐mode column, which combines separation based on both charge and hydrophobicity.
Jakob Haglöf +2 more
wiley +1 more source
Short-term sequence evolution and vertical inheritance of the
BMC Evolutionary Biology, 2006 Background Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene.
De Jonckheere Johan F +3 more
doaj +1 more source
Acta Crystallographica Section D, Volume 81, Issue 8, Page 410-422, August 2025.Q‐scores are calculated for atomic models derived from 3D electron microscopy maps, measure how well the model fits the map and reflect the quality of the map itself. Here, we develop a statistical model for Q‐scores applied to many maps and models in the EMDB and PDB, respectively, and show how it can be used to assess the reliability of entire models
Grigore Pintilie +8 more
wiley +1 more source
RNA, 2015 I had arranged to meet Tom Cech after the Pfizer Lecture he was giving at Harvard. This was 1986, RNA catalysis was pretty new, and I was a graduate student nearby at Brandeis interested in discussing with Tom the possibility of joining his group for a postdoc. His lecture was masterful—the audience in rapt attention. We all knew, and were taught, that
openaire +3 more sources
Probing complex RNA structures by mechanical force
, 2003 RNA secondary structures of increasing complexity are probed combining single molecule stretching experiments and stochastic unfolding/refolding simulations. We find that force-induced unfolding pathways cannot usually be interpretated by solely invoking
A. Xayaphoummine +36 more
core +3 more sources
JHEP Reports, 2023 Background & Aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster progression towards cirrhosis, liver decompensation, and hepatocellular carcinoma.
Eirini D. Tseligka +5 more
doaj
Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]
, 2010 Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Noeske, Jonas +2 more
core
A Cross-chiral RNA Polymerase Ribozyme
Nature, 2014 Thirty years ago it was shown that the non-enzymatic, template-directed polymerization of activated mononucleotides proceeds readily in a homochiral system, but is severely inhibited by the presence of the opposing enantiomer. This finding poses a severe
Jonathan T. Sczepanski, G. F. Joyce
semanticscholar +1 more source
Ribozymes, genomics and therapeutics
Chemistry & Biology, 1999 Genome-sequencing projects are proceeding at a rapid pace and determining the function of open reading frames is the next great challenge. Ribozymes with site-specific cleaving activity could aid greatly in this process. High-throughput screening methods to identify optimal target sites for ribozyme cleavage will provide tools for functional genomics ...
openaire +3 more sources