Results 121 to 130 of about 28,198 (287)
Factors determining chromosomal localization of transposable elements in plants
Plant Biology, EarlyView.We review transposon chromosomal niches, and the functional consequences of their specific chromosomal localization in plants. Abstract Transposable elements (TEs) constitute a significant part of plant genomes and shape their genomic landscape. While some TEs are ubiquitously dispersed, other elements specifically occupy discrete genomic loci.
E. Kejnovsky +3 more
wiley +1 more source
Minimal models for proteins and RNA: From folding to function [PDF]
arXiv, 2008 We present a panoramic view of the utility of coarse-grained (CG) models to study folding and functions of proteins and RNA. Drawing largely on the methods developed in our group over the last twenty years, we describe a number of key applications ranging from folding of proteins with disulfide bonds to functions of molecular machines. After presenting
arxiv
RNA, 2015 I had arranged to meet Tom Cech after the Pfizer Lecture he was giving at Harvard. This was 1986, RNA catalysis was pretty new, and I was a graduate student nearby at Brandeis interested in discussing with Tom the possibility of joining his group for a postdoc. His lecture was masterful—the audience in rapt attention. We all knew, and were taught, that
openaire +3 more sources
Eukaryotic Penelope-Like Retroelements Encode Hammerhead Ribozyme Motifs
Molecular biology and evolution, 2014 Small self-cleaving RNAs, such as the paradigmatic Hammerhead ribozyme (HHR), have been recently found widespread in DNA genomes across all kingdoms of life.
Amelia Cervera, M. de la Peña
semanticscholar +1 more source
Click Conjugates of Artificial Ribonucleases: Sequence Specific Cleavage with Multiple Turnover
Chemistry – A European Journal, Volume 31, Issue 30, May 27, 2025.A trisbenzimidazole catalyst was attached to central positions of DNA and DNA‐LNA oligonucleotides. The resulting conjugates bind complementary RNA strands and cleave them with multiple turnover and substrate half‐lives down to 3.5 hours. Up to 98.8% of cleavage occurs in a single site.
Sandra Weber +4 more
wiley +1 more source
Screening for Important Base Identities in the Hairpin Ribozyme by In Vitro Selection for Cleavage
BioTechniques, 1998 Random mutagenesis followed by an in vitro selection procedure was shown to be capable of identifying important bases of the hairpin ribozyme for cleavage of an RNA target sequence.
Andrew Siwkowski +3 more
doaj +1 more source
Synthesis of circular RNA in bacteria and yeast using RNA cyclase ribozymes derived from a group I intron of phage T4. [PDF]
, 1994 E. Ford, Manuel Ares
openalex +1 more source
Nanosecond Hyperquenching for Electron Cryo‐Microscopy Without Air‐Water Interface Artifacts
Chemistry – A European Journal, Volume 31, Issue 29, May 22, 2025.A novel method for the ultrafast vitrification of the biological assemblies is assayed by the electron cryotomography. Protein specimens prepared by this method inherently lack the spatial/structural artifacts, which derive from the surface tension at the air‐water interface (AWI).
Utz H. Ermel +2 more
wiley +1 more source
Two-dimensional chemical mapping for non-coding RNAs [PDF]
arXiv, 2011 Non-coding RNA molecules fold into precise base pairing patterns to carry out critical roles in genetic regulation and protein synthesis. We show here that coupling systematic mutagenesis with high-throughput SHAPE chemical mapping enables accurate base pair inference of domains from ribosomal RNA, ribozymes, and riboswitches.
arxiv
Ribozymes, genomics and therapeutics
Chemistry & Biology, 1999 Genome-sequencing projects are proceeding at a rapid pace and determining the function of open reading frames is the next great challenge. Ribozymes with site-specific cleaving activity could aid greatly in this process. High-throughput screening methods to identify optimal target sites for ribozyme cleavage will provide tools for functional genomics ...
openaire +3 more sources