Results 161 to 170 of about 16,956 (222)

Exploring the space of self-reproducing ribozymes using generative models. [PDF]

Nat Commun
Lambert CN, Opuu V, Calvanese F, Pavlinova P, Zamponi F, Hayden EJ, Weigt M, Smerlak M, Nghe P.   +8 more
europepmc   +1 more source

Exploiting conformational changes in a caffeine aptamer to engineer synthetic RNA devices. [PDF]

Nucleic Acids Res
Kraus L, Gunawan VJ, Johannson R, Hallstein S, Block S, Campbell GA, Alameen A, Rosser SJ, Mol AA, Suess B.   +9 more
europepmc   +1 more source

Generative inverse design of RNA structure and function with gRNAde

Joshi CK, Gianni E, Kwok SLY, Mathis SV, Liò P, Holliger P.   +5 more
europepmc   +1 more source

Circularly-Permuted Pistol Ribozyme: A Synthetic Ribozyme Scaffold for Mammalian Riboswitches

ACS Synthetic Biology, 2021
A small molecule-responsive self-cleaving ribozyme (aptazyme) embedded in the untranslated region of an mRNA functions as a riboswitch that allows chemical regulation of gene expression in mammalian cells.
Kamila Mustafina, Yoko Nomura, Rachapun Rotrattanadumrong   +2 more
exaly   +2 more sources

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Ribozymes: the hairpin and Varkud ribozymes are related.

Rivista di biologia, 2004
The hairpin ribozyme of plant virusoids and the Varkud ribozyme from a retroplasmid of fungal mitochondria show notable similarities in sequence and secondary structure. Some more distant inter-relationships appear to exist between this pair, the viroid/virusoid hammerhead and the hepatitis delta ribozyme.
Elder, David, Harris, Ray J.
openaire   +2 more sources

Ribozyme-Catalyzed Transcription of an Active Ribozyme

Science, 2011
A functional RNA has been synthesized by an RNA enzyme from mononucleotide building blocks.
Aniela, Wochner, James, Attwater, Alan, Coulson, Philipp, Holliger   +3 more
openaire   +2 more sources

The hammerhead ribozyme

Biopolymers, 1999
The hammerhead ribozyme is an intriguing RNA molecule with the ability to serve as a catalyst to cleave sequence-specifically RNA molecules in an intermolecular reaction. Preferentially Mg(2+) is required for optimal activity by inducing the catalytically competent conformation and by possibly acting as an acid-base catalyst.
F, Eckstein, B, Bramlage
openaire   +2 more sources

Ribozymes in Wonderland

Science, 1997
Robertson, Michael P. Bull, Jim On p. [614][1] of this issue, Wright and Joyce report the successful evolution of a catalytic ribozyme selected for its ability to perform ligation. In their Perspective, Ellington et al . comment on the advances in this study over previous efforts and what this work tells us about evolution.
A D, Ellington, M P, Robertson, J, Bull
openaire   +2 more sources