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Reprogramming the tumor microenvironment with c-MYC-based gene circuit platform to enhance specific cancer immunotherapy. [PDF]
Nat CommunZhan H +11 more
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From experimental clues to theoretical modeling: Evolution associated with the membrane-takeover at an early stage of life. [PDF]
PLoS Comput BiolMa W, Yu C.
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Ribozymes: the hairpin and Varkud ribozymes are related.
Rivista di biologia, 2004The hairpin ribozyme of plant virusoids and the Varkud ribozyme from a retroplasmid of fungal mitochondria show notable similarities in sequence and secondary structure. Some more distant inter-relationships appear to exist between this pair, the viroid/virusoid hammerhead and the hepatitis delta ribozyme.
Elder, David, Harris, Ray J.
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Ribozyme-Catalyzed Transcription of an Active Ribozyme
Science, 2011A functional RNA has been synthesized by an RNA enzyme from mononucleotide building blocks.
Aniela, Wochner +3 more
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Science, 1997
Robertson, Michael P. Bull, Jim On p. [614][1] of this issue, Wright and Joyce report the successful evolution of a catalytic ribozyme selected for its ability to perform ligation. In their Perspective, Ellington et al . comment on the advances in this study over previous efforts and what this work tells us about evolution.
A D, Ellington, M P, Robertson, J, Bull
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Robertson, Michael P. Bull, Jim On p. [614][1] of this issue, Wright and Joyce report the successful evolution of a catalytic ribozyme selected for its ability to perform ligation. In their Perspective, Ellington et al . comment on the advances in this study over previous efforts and what this work tells us about evolution.
A D, Ellington, M P, Robertson, J, Bull
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Biopolymers, 1999
The hammerhead ribozyme is an intriguing RNA molecule with the ability to serve as a catalyst to cleave sequence-specifically RNA molecules in an intermolecular reaction. Preferentially Mg(2+) is required for optimal activity by inducing the catalytically competent conformation and by possibly acting as an acid-base catalyst.
F, Eckstein, B, Bramlage
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The hammerhead ribozyme is an intriguing RNA molecule with the ability to serve as a catalyst to cleave sequence-specifically RNA molecules in an intermolecular reaction. Preferentially Mg(2+) is required for optimal activity by inducing the catalytically competent conformation and by possibly acting as an acid-base catalyst.
F, Eckstein, B, Bramlage
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Biochemical Society Transactions, 2002
The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic and 5′-hydroxy termini. The cleavage rate is approx.
K F, Blount, O C, Uhlenbeck
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The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic and 5′-hydroxy termini. The cleavage rate is approx.
K F, Blount, O C, Uhlenbeck
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Current Opinion in Biotechnology, 1992
RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation.
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RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation.
openaire +2 more sources