Results 171 to 180 of about 558,329 (279)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Computational Characterization of the Energetics, Structure, and Spectroscopy of Biofuel Precursors: The Case of Furfural-Acetone-Furfural. [PDF]

J Comput Chem
Benmoussa NC, Alessandrini S, de Boer L, Azizi S, Friha H, Bachir R, Hochlaf M, Puzzarini C, Linguerri R.   +8 more
europepmc   +1 more source

Scalable, Microwave‐Enabled Synthesis of Ternary WxTi1‐xO2 and Heterostructured TiO2‐WO3‐x Colloidal Nanocrystals: Carrier Dynamics and Photocatalytic Properties

Advanced Science, EarlyView.
Two microwave‐assisted synthetic methods, specifically a one‐pot and a seeded‐growth approach, are developed within a hydroalcoholic solution for the growth of single‐phase ternary WxTi1‐xO2 and heterostructured TiO2‐WO3‐x colloidal nanocrystals. Both types of nanocrystals show significant photocatalytic activity for 4‐methoxybenzyl alcohol oxidation ...
Riccardo Scarfiello, Michele Guizzardi, Angela Fiore, Armando Genco, Concetta Nobile, Elisabetta Perrone, Sara Fernanda Orsini, Clémentine Fellah, Lucian Roiban, Marianna Bellardita, Anna Maria Venezia, Giulio Cerullo, Leonardo Palmisano, Luigi Carbone   +13 more
wiley   +1 more source

Epigenetic crosstalk between uric acid and vascular health: a role for extracellular vesicles. [PDF]

Clin Epigenetics
Schiano C, Napoli C.
europepmc   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Free D-aspartate modulates the expression of proteins linked to schizophrenia and autism spectrum disorder during early postnatal life. [PDF]

Cell Mol Life Sci
Errico F, Russo R, Carrillo F, Nuzzo T, di Vito R, Canonico E, Pedone PV, Di Cunto F, Esposito T, Usiello A, Chambery A.   +10 more
europepmc   +1 more source

Unraveling Energy Flow Mechanisms in Semiconductors by Ultrafast Spectroscopy: Germanium as a Case Study

Advanced Science, EarlyView.
A multi‐technique pump‐probe setup capable of performing both transient reflectivity and time‐resolved Raman spectroscopy after ultrafast excitation, provides a comprehensive understanding of ultrafast electronic and phononic processes. Distinct decay rates for the temperature, frequency, and linewidth of the phonon mode in germanium are observed ...
Grazia Raciti, Begoña Abad, Riccardo Dettori, Raja Sen, Aswathi K. Sivan, Jose M. Sojo‐Gordillo, Nathalie Vast, Riccardo Rurali, Claudio Melis, Jelena Sjakste, Ilaria Zardo   +10 more
wiley   +1 more source

Association Between Point-of-Care Viral Testing for Influenza and Adenovirus and Antibiotic Management in a Pediatric Emergency Department in Italy. [PDF]

Children (Basel)
Bellini T, Lacovara A, Franzone D, Mariani M, Iovinella G, Virgilio M, Lasagna J, Matarese S, Pepino C, Canzoneri F, Guazzi M, Piccotti E, Moscatelli A.   +12 more
europepmc   +1 more source

MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection

Advanced Science, EarlyView.
MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani, Luca Capelli, Denise Di Lena, Alejandro Chamorro‐Garcia, Rudy Ippodrino, Alessandro Porchetta, Alessandro Bertucci   +6 more
wiley   +1 more source

AI-derived five-gene signature predicts risk in multiple myeloma under bortezomib-based therapy. [PDF]

Sci Rep
Gargano G, Pappagallo SA, Quinto AM, Rossini B, Gramegna D, Mondelli P, Vegliante MC, Opinto G, Esposito F, Zaccaria GM, Solli V, Palumbo O, Terragna C, Cavo M, Del Buono N, Guarini A, Ciavarella S.   +16 more
europepmc   +1 more source