Results 251 to 260 of about 72,471 (294)
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JAMA: The Journal of the American Medical Association, 1978
RIFAMPIN is a potent antibiotic with the capacity for serious and unusual side effects, even in therapeutic dosages. 1,2 Deaths in patients taking therapeutic dosages have been attributed to an unknown immunologic mechanism and have occurred almost exclusively in patients taking the drug at irregular intervals. 3 Massive overdose, "the red man syndrome,
Richard O. Broadwell +2 more
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RIFAMPIN is a potent antibiotic with the capacity for serious and unusual side effects, even in therapeutic dosages. 1,2 Deaths in patients taking therapeutic dosages have been attributed to an unknown immunologic mechanism and have occurred almost exclusively in patients taking the drug at irregular intervals. 3 Massive overdose, "the red man syndrome,
Richard O. Broadwell +2 more
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Rifampin in the Treatment of Leprosy
Clinical Infectious Diseases, 1983The minimal inhibitory concentration of rifampin for Mycobacterium leprae is less than 1 microgram/ml. Therapy with rifampin has proved efficacious both in mice experimentally infected with M. leprae and in humans with leprosy. Rifampin kills M. leprae more rapidly than do other antileprosy drugs currently available. Consequently, M.
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Interaction of Rifampin and Digitoxin
Archives of Internal Medicine, 1983In a patient who had been receiving digitoxin therapy, the serum digitoxin level decreased markedly when rifampin was added to the therapeutic regimen. The serum digitoxin level returned to the pretreatment level when rifampin therapy was discontinued.
Diana M. Poor +2 more
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Inhibition of Cytomegalovirus by Rifampin
Journal of Infectious Diseases, 1972Rifampin at a concentration of 150 gtg/ml interfered with the replication of Davis, Kerr, and AD 169 strains of cytomegalovirus in Wi-38 cells. The replication of herpes-simplex virus (types 1 and 2) and Sindbis virus in the same cells was unaffected by a similar concentration of the antibiotic.
Paul S. Lietman +2 more
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Interaction of Rifampin and Warfarin
Chest, 1975A 72-year-old man who had been taking rifampin daily for several months was concurrently administered warfarin daily for ten weeks. During this period, the prothrombin time (PT) rose remarkably little as the dosage of warfarin was increased. With difficulty, satisfactory anticoagulation was achieved by giving warfarin 20 mg daily. On discontinuation of
Robert B. Mann, Timothy H. Self
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Archives of Internal Medicine, 1987
To the Editor. —In their recent article, Baciewicz et al 1 presented an excellent update on rifampin drug interactions. There are, however, two therapeutic agents (ethionamide and protionamide) not mentioned that may have serious to potentially fatal consequences when used with rifampin.
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To the Editor. —In their recent article, Baciewicz et al 1 presented an excellent update on rifampin drug interactions. There are, however, two therapeutic agents (ethionamide and protionamide) not mentioned that may have serious to potentially fatal consequences when used with rifampin.
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Clinical Pharmacology and Therapeutics, 1984
Digoxin doses required to maintain therapeutic serum concentrations rose substantially in two patients dependent on dialysis with the commencement of rifampin therapy. When rifampin was discontinued, doses fell to requirements before rifampin. Serum digoxin concentration may fall to ineffective levels with rifampin therapy and rise to potentially toxic
Linda Longerich +3 more
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Digoxin doses required to maintain therapeutic serum concentrations rose substantially in two patients dependent on dialysis with the commencement of rifampin therapy. When rifampin was discontinued, doses fell to requirements before rifampin. Serum digoxin concentration may fall to ineffective levels with rifampin therapy and rise to potentially toxic
Linda Longerich +3 more
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Clinical Infectious Diseases, 1983
Rifampin has proved to be a valuable antibiotic with relatively few major adverse effects. Its toxicity is predominantly hepatic and immunoallergic in character. While hepatic toxicity is dose related and has been observed mainly in patients with underlying liver disease, the immunoallergic effects are usually associated with intermittent or prolonged ...
Stephanie Leventis, Jacques H. Grosset
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Rifampin has proved to be a valuable antibiotic with relatively few major adverse effects. Its toxicity is predominantly hepatic and immunoallergic in character. While hepatic toxicity is dose related and has been observed mainly in patients with underlying liver disease, the immunoallergic effects are usually associated with intermittent or prolonged ...
Stephanie Leventis, Jacques H. Grosset
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Clinical Infectious Diseases, 1983
Rifampin and amphotericin B were found to be synergistic in vitro against Saccharomyces cerevisiae, Histoplasma capsulatum, and several species of Aspergillus, The uptake of rifampin by the fungi was increased in the presence of amphotericin B, and this increase probably formed the basis for the synergistic activity observed.
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Rifampin and amphotericin B were found to be synergistic in vitro against Saccharomyces cerevisiae, Histoplasma capsulatum, and several species of Aspergillus, The uptake of rifampin by the fungi was increased in the presence of amphotericin B, and this increase probably formed the basis for the synergistic activity observed.
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History of the Development of Rifampin [PDF]
Clinical Infectious Diseases, 1983 Rifampin was developed in the Dow-Lepetit Research Laboratories (Milan, Italy) as part of an extensive program of chemical modification of the rifamycins, the natural metabolites of Nocardia mediterranei. One peculiar fact was that all of the studies leading to highly active derivatives were performed on a molecule (rifamycin B) that was itself ...
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