Results 1 to 10 of about 16,739,290 (349)

Variability in COVID-19 in-hospital mortality rates between national health service trusts and regions in England: A national observational study for the Getting It Right First Time Programme

EClinicalMedicine, 2021
Background: A key first step in optimising COVID-19 patient outcomes during future case-surges is to learn from the experience within individual hospitals during the early stages of the pandemic.
William K. Gray, Annakan V Navaratnam, Jamie Day, Pratusha Babu, Shona Mackinnon, Ini Adelaja, Sam Bartlett-Pestell, Chris Moulton, Cliff Mann, Anna Batchelor, Michael Swart, Chris Snowden, Philip Dyer, Michael Jones, Martin Allen, Adrian Hopper, Gerry Rayman, Partha Kar, Andrew Wheeler, Sue Eve-Jones, Kevin J Fong, John T Machin, Julia Wendon, Tim W.R. Briggs   +23 more
doaj   +1 more source

Factors associated with an interruption in treatment of people living with HIV in USAID-supported states in Nigeria: a retrospective study from 2000–2020

BMC Public Health, 2021
Background Patient interruption of antiretroviral therapy (ART) continues to limit HIV programs’ progress toward epidemic control. Multiple factors have been associated with client interruption in treatment (IIT)— including age, gender, CD4 count, and ...
Silviu Tomescu, Thomas Crompton, Jonathan Adebayo, Constance Wose Kinge, Francis Akpan, Marcus Rennick, Charles Chasela, Evans Ondura, Dauda Sulaiman Dauda, Pedro T. Pisa   +9 more
doaj   +1 more source

Factors associated with viral load non-suppression in people living with HIV on ART in Nigeria: cross-sectional analysis from 2017 to 2021

BMJ Open, 2023
Objectives Identify factors (demographic and clinical) associated with a non-suppressed viral load (VL) of people living with HIV (PLHIV) on antiretroviral therapy (ART) in Nigeria.Design Cross-sectional study.Setting Sixteen US Agency for International ...
Charles Chasela, Silviu Tomescu, Thomas Crompton, Jonathan Adebayo, Francis Akpan, Dauda Sulaiman Dauda, Zola Allen, Evans Odhiambo Ondura, Constance Wose Kinge, Pedro Pisa   +9 more
doaj   +1 more source

Amelioration of experimental autoimmune encephalomyelitis by in vivo reprogramming of macrophages using pro-resolving factors

Journal of Neuroinflammation, 2023
Background Reinstating inflammation resolution represents an innovative concept to regain inflammation control in diseases marked by chronic inflammation. While most therapeutics target inflammatory molecules and inflammatory effector cells and mediators,
Thierry Gauthier, Omayra Martin-Rodriguez, Cécile Chagué, Anna Daoui, Adam Ceroi, Alexis Varin, Francis Bonnefoy, Séverine Valmary-Degano, Mélanie Couturier, Susanne Behlke, Philippe Saas, Pierre-François Cartron, Sylvain Perruche   +12 more
doaj   +1 more source

Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia

Journal for ImmunoTherapy of Cancer, 2022
Background Acute myeloid leukemia (AML) remains a very difficult disease to cure due to the persistence of leukemic stem cells (LSCs), which are resistant to different lines of chemotherapy and are the basis of refractory/relapsed (R/R) disease in 80% of
Vincent Alcazer, Marina Deschamps, Etienne Daguindau, Eric Robinet, Eric Deconinck, Denis Caillot, Stephane Depil, Rim Trad, Walid Warda, Mathieu Neto da Rocha, Ana Berceanu, Clémentine Nicod, Rafik Haderbache, Xavier Roussel, Yohan Desbrosses, Florain Renosi, Christophe Roumier, Lucie Bouquet, Sabeha Biichle, Melanie Guiot, Evan Seffar, Yahya Salma, Christophe Ferrand   +22 more
doaj   +1 more source

The Conflict between Citizens' Right to Privacy and the State's Right to Digitally Tracking People Infected or Suspected of Transmitting the Covid-19 Virus [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2022
The proliferation of Coronavirus around the world and the need to maintain the health of individuals in society have forced many governments to impose restrictions on citizens' rights by imposing social distances, quarantine and closure of educational ...
Sattar Azizi, Zahra Ghadbeygi
doaj   +1 more source

Efficiency of human monocyte-derived suppressor cell-based treatment in graft-versus-host disease prevention while preserving graft-versus-leukemia effect

OncoImmunology, 2021
Background Immunosuppressive cell-based therapy is a recent strategy for controlling Graft-versus-Host Disease (GvHD). Such cells ought to maintain their suppressive function in inflammatory conditions and in the presence of immunosuppressive agents ...
Nona Janikashvili, Claire Gérard, Marine Thébault, Andrea Brazdova, Clovis Boibessot, Claudie Cladière, Marion Ciudad, Hélène Greigert, Séthi Ouandji, Thibault Ghesquière, Maxime Samson, Sylvain Audia, Philippe Saas, Bernard Bonnotte   +13 more
doaj   +1 more source

Applying machine learning and predictive modeling to retention and viral suppression in South African HIV treatment cohorts

Scientific Reports, 2022
HIV treatment programs face challenges in identifying patients at risk for loss-to-follow-up and uncontrolled viremia. We applied predictive machine learning algorithms to anonymised, patient-level HIV programmatic data from two districts in South Africa,
Mhairi Maskew, Kieran Sharpey-Schafer, Lucien De Voux, Thomas Crompton, Jacob Bor, Marcus Rennick, Admire Chirowodza, Jacqui Miot, Seithati Molefi, Chuka Onaga, Pappie Majuba, Ian Sanne, Pedro Pisa   +12 more
doaj   +1 more source

Predictive biomarkers and specific immune responses of COVID-19 mRNA vaccine in patients with cancer: prospective results from the CACOV-VAC trial

BMJ Oncology, 2023
Objective Vaccinated patients with cancer in follow-up studies showed a high seropositivity rate but impaired antibody titres and T cell responses following mRNA vaccine against COVID-19.
Laura Mansi, Olivier Adotevi, Marie Kroemer, Laurie Spehner, Adeline Bouard, Marine Jary, Romain Loyon, Christophe Borg, Dewi Vernerey, Syrine Abdeljaoued, Myriam Ben Khelil, Quentin Lepiller, Emeline Orillard, Antoine Falcoz, Hamadi Almotlak, Stefano Kim, Elsa Curtit, Guillaume Meynard, Charlee Nardin, Kamal Asgarov, Ugo Chartral, Virginie Mougey, Morgane Lopez   +22 more
doaj   +1 more source

Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics

Frontiers in Oncology, 2020
Recent studies have provided several insights into acute myeloid leukemia. Studies based on molecular biology have identified eight functional mutations involved in leukemogenesis, including driver and passenger mutations.
Xavier Roussel, Xavier Roussel, Etienne Daguindau, Etienne Daguindau, Ana Berceanu, Yohan Desbrosses, Walid Warda, Mathieu Neto da Rocha, Rim Trad, Eric Deconinck, Eric Deconinck, Marina Deschamps, Christophe Ferrand   +12 more
doaj   +1 more source