Results 91 to 100 of about 1,765,259 (347)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Wrinkling criteria in sheet metal forming for single sided contact situation and its application [PDF]

open access: yes, 2005
The general wrinkling theory based on the rate formulation of the principle of virtual work has been applied in a number of studies on wrinkling during sheet metal forming. No contact with the die was allowed.
Huetink, Han   +2 more
core   +1 more source

Quando a morte é um ato de cuidado: obstinação terapêutica em crianças

open access: yesCadernos de Saúde Pública
Este artigo discute um caso específico de recusa de obstinação terapêutica para um bebê de oito meses, portador de Amiotrofia Espinhal Progressiva Tipo I, uma doença genética incurável, degenerativa e com curto prognóstico médico de sobrevida.
Debora Diniz
doaj  

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

What medical conditions lead to a request for euthanasia? A rapid scoping review

open access: yesHealth Science Reports
Background and Aims Euthanasia is a controversial issue related to the right to die. Although euthanasia is mostly requested by terminally sick individuals, even in societies where it is legal, it is unclear what medical conditions lead to euthanasia ...
Zahra Rahimian   +6 more
doaj   +1 more source

Cuidados paliativos, la perspectiva de la muerte como parte del proceso de vida

open access: yesENE. Revista de Enfermería
El concepto de dignidad humana, el sentido de la vida, de la libertad, afectan al sentido de la muerte. Los cuidados paliativos manejan con escrupulosidad y de forma correcta estas expresiones del final de vida, que definen situaciones muy concretas y ...
Gemma Llauradó Sanz
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

A Tale of Two \u3ci\u3eLochners\u3c/i\u3e: The Untold History of Substantive Due Process and the Idea of Fundamental Rights [PDF]

open access: yes, 2009
To say that the Supreme Court\u27s decision in Lochner v. New York is infamous is an understatement. Scholars remember Lochner for its strong right to contract and laissez-faire ideals--at least that is the conventional account of the case.
Nourse, Victoria
core   +1 more source

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