Results 81 to 90 of about 194,334 (235)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Transformations des conditions du mourir et nouvelles formes de socialisation à la mort

Droit et Cultures, 2018
This article shows that the process of end-of-life individualization cannot be dissociated from the recent emergence of new forms of socialization to death and dying.
Michel Castra
doaj  

Exploring perspectives of Scottish medical students on the proposed ‘Assisted Dying for Terminally Ill Adults (Scotland)’ Bill

BMC Medical Ethics
Background The debate over legalising assisted dying is complex and multifaceted, eliciting strong and diverse opinions from all involved parties. Recently, the Scottish Parliament held an initial vote on the issue, opting to progress with proposed ...
David Geddes, Josh Knox, David Obree, Jeni Harden   +3 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Cuidados paliativos, la perspectiva de la muerte como parte del proceso de vida

ENE. Revista de Enfermería
El concepto de dignidad humana, el sentido de la vida, de la libertad, afectan al sentido de la muerte. Los cuidados paliativos manejan con escrupulosidad y de forma correcta estas expresiones del final de vida, que definen situaciones muy concretas y ...
Gemma Llauradó Sanz
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Limitação de esforço terapêutico na pessoa com lesão encefálica grave

Revista Bioética
As discussões a respeito das condutas de limitação de esforço terapêutico (LET) são frequentes nas unidades de terapia intensiva e na especialidade médica oncológica e são também importantes em contextos hospitalares de internação de longa permanência ...
Henrique de Alencar Gomes, Mônica Adelaide Almeida, Terezinha Valéria Ferreira Matoso, Maria Angélica Assunção Viana, Maria Bernadete Cardoso Rezende, Maíza Ângela Ferreira Bento, Tatiane Santos Fonseca Guimarães, Sabrina Vilane de Oliveira Alcântara, Ary Demétrio Júnior, Ana Paula Gomes Costa Silva, Cibele Renata de Paula Moreira, Daniela Simplício Vieira Albergaria, Marília Káthya Coutinho, Marli Medeiros, Roseli Melo Silva de Souza, Polianna Cristina Pires Dumont   +15 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source