Results 61 to 70 of about 260,425 (270)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Collaboration and research imperatives for a growing right-to-die movement. [PDF]
Can J Public Health, 2023 Dankwort J.
europepmc +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
, 2014 This entry opens with a concise history of the right to die movement. Then it provides a conceptual framework, explaining key terms that are often utilized by those who advocate physician aid-in-dying: liberty, autonomy, dignity, respect, concern, quality of life and suffering.
openaire +3 more sources
Quando a morte é um ato de cuidado: obstinação terapêutica em crianças
Cadernos de Saúde PúblicaEste artigo discute um caso específico de recusa de obstinação terapêutica para um bebê de oito meses, portador de Amiotrofia Espinhal Progressiva Tipo I, uma doença genética incurável, degenerativa e com curto prognóstico médico de sobrevida.
Debora Diniz
doaj
Criminologie, 2018 À partir de recherches ethnographiques menées auprès d’activistes du droit à la mort, cet article cherche à relever et à analyser les divisions de nature conceptuelle qui structurent les arguments des activistes.
Ari Gandsman
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Assisted Suicide and Euthanasia in Mental Disorders: Ethical Positions in the Debate between Proportionality, Dignity, and the Right to Die. [PDF]
Healthcare (Basel), 2023 Scopetti M +8 more
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source