Results 51 to 60 of about 92,832,169 (281)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

The fight-to-die: older people and death activism

open access: yesInternational Journal of Ageing and Later Life, 2012
This article explores the activities and convictions of older right-to-die activists who belong to a small but very active interest group based in Scotland, UK, called Friends at the End (FATE).
Naomi Richards
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Personal Papers (MS 80-0002)

open access: yes, 1963
Report from National Right to Work Committee discussing the committee's activities and involvement around the ...
National Right to Work Committee
core  

¿Derecho a morir con dignidad?

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2008
El derecho a morir con dignidad es un concepto vago y que recibe múltiples interpretaciones, muchas de ellas inapropiadas. Se propone la necesidad de que sea el médico quien se haga responsable de proteger los derechos del paciente, de garantizar el uso ...
Álvaro Ruiz
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Revisiting the Right to Die with Dignity A Critical Look at Karnataka’s Progressive Approach to Autonomy [PDF]

open access: yes
The right to life and personal liberty is recognised as a fundamental right under Article 21 of the Indian Constitution. It is important to note that Article 21 has been interpreted quite inclusively by the Indian Supreme Court, reading into its ambit ...
Parmaar, Sakkcham Singh   +1 more
core  

Unintended consequences: local housing allowance meets the right to buy [PDF]

open access: yes, 2012
Recent rapid expansion of the Private Rented Sector (PRS) is recognised but the extensive involvement of ex local authority stock in this new PRS is not.
Sprigings, N.   +3 more
core   +1 more source

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