Results 71 to 80 of about 92,832,169 (281)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 1968 Monthly newsletter published from National Right to Work Committee summarizing the lobbying activities of the committee at the national level of government, highlights of a recent Right to Work seminar held in San Francisco, California, and a report of ...
National Right to Work Committee (U.S.)
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Right to Live: The Right to Die (Book Review) [PDF]
, 1977 Reviewed Title: The Right to Live: The Right to Die by C.
Taylor, E. L. Hebden
core +1 more source
Quando a morte é um ato de cuidado: obstinação terapêutica em crianças
Cadernos de Saúde PúblicaEste artigo discute um caso específico de recusa de obstinação terapêutica para um bebê de oito meses, portador de Amiotrofia Espinhal Progressiva Tipo I, uma doença genética incurável, degenerativa e com curto prognóstico médico de sobrevida.
Debora Diniz
doaj
Psychological Suffering and the Right to Die: An Islamic Legal Assessment of Euthanasia Requests
ReligionsThis study offers a critical re-examination of contemporary euthanasia debates through an Islamic legal lens, with particular focus on requests for euthanasia arising from psychological suffering within the context of mental disorders.
Tuba Erkoç Baydar, Rakia Erkoç Çelik
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Collaboration and research imperatives for a growing right-to-die movement. [PDF]
Can J Public Health, 2023 Dankwort J.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source