Results 41 to 50 of about 4,155,575 (342)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

The Kuramoto-Sivashinsky Equation [PDF]

Notices Amer. Math. Soc. 69 (2022), 1581-1583, 2022
The Kuramoto-Sivashinsky equation was introduced as a simple 1-dimensional model of instabilities in flames, but it turned out to mathematically fascinating in its own right. One reason is that this equation is a simple model of Galilean-invariant chaos with an arrow of time.
arxiv  

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Testamento vital na prática médica: compreensão dos profissionais

Revista Bioética
Resumo O testamento vital é tema discutido no âmbito da saúde e do direito, e importante instrumento para direcionar a assistência prestada ao paciente terminal de acordo com suas aspirações.
Márcia Adriana Dias Meirelles Moreira, Solange Fátima Geraldo da Costa, Mônica Lorena Dias Meirelles da Cunha, Ana Aline Lacet Zaccara, Melissa Negro-Dellacqua, Fernando Dutra   +5 more
doaj   +1 more source

A Knowledge base model for complex forging die machining [PDF]

Computers & Industrial Engineering 61 (2011) pp. 84-97, 2011
Recent evolutions on forging process induce more complex shape on forging die. These evolutions, combined with High Speed Machining (HSM) process of forging die lead to important increase in time for machining preparation. In this context, an original approach for generating machining process based on machining knowledge is proposed in this paper.
arxiv   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Der Whitneysche Fortsetzungssatz für vektorwertige Funktionen [PDF]

arXiv, 2023
Let $k\in\mathbb{N}_0\cup\{\infty\}$. According to Whitney's extension theorem, each real-valued Whitney $k$-Jet on a closed subset $A\subseteq\mathbb{R}^n$ can be extended to a $C^k$-function on $\mathbb{R}^n$. Based on Whitney's original work, we prove analogous results for jets and functions with values in a real Hausdorff locally convex topological
arxiv  

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

The Constitutional Right to Die: Ethical Considerations [PDF]

, 1997
In this commentary, the author first looks at some ethical reasoning supporting physician-assisted dying. Second, he examines some of the lines that have been drawn between withdrawing and withholding life-sustaining treatment on the one hand, and ...
Gostin, Lawrence O.
core   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source