The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang+15 more
wiley +1 more source
Differences of disease progression in congestive heart failure due to alcoholic as compared to idiopathic dilated cardiomyopathy [PDF]
In patients with alcoholic cardiomyopathy there is evidence that mild heart failure is reversible if patients abstain from alcohol, but there is no consensus whether the disease is progressive once structural myocardial dilatation has evolved. The aim of
Burkart, F.+4 more
core
Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study [PDF]
OBJECTIVES: To characterise the clinical features of patients with suspected heart failure but preserved left ventricular systolic function to determine if they have other potential causes for their symptoms rather than being diagnosed with 'diastolic ...
Caruana, L.+3 more
core +2 more sources
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu+16 more
wiley +1 more source
Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J+18 more
core +1 more source
Early postoperative interventional ASD-closure for severe atrial right to left shunt in a neonate with common arterial trunk [PDF]
Although closure of an atrial septal defect (ASD II) with an occluding device in the first year of life is not a routine procedure, it is a feasible treatment, even in neonates.
Dilber, Daniel+2 more
core +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang+4 more
wiley +1 more source
Objectives This cross-sectional analysis from the CZecking Heart Failure in patients with advanced Chronic Kidney Disease trial (ISRCTN18275480) examined pulmonary hypertension and right ventricular-pulmonary arterial coupling in patients on chronic ...
Kristina Buryskova Salajova+11 more
doaj +1 more source
The Pulmonary Component of the Second Sound in Right Ventricular Failure [PDF]
Sound within the pulmonary artery was measured in 24 patients to determine if right ventricular failure modifies the amplitude of the pulmonary component of the second sound (P2).
Anbe, Daniel T.+3 more
core +1 more source
miR-21 is associated with fibrosis and right ventricular failure.
Combined pulmonary insufficiency (PI) and stenosis (PS) is a common long-term sequela after repair of many forms of congenital heart disease, causing progressive right ventricular (RV) dilation and failure.
Sushma Reddy+10 more
semanticscholar +1 more source