Results 41 to 50 of about 2,225,816 (243)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Dynamic Simulation for Driver-Tricycle-Road System with Rigid-Flexible Coupling

, 2011
Performance simulation for driver-tricycle-road hasn’t been reported currently. According to rigid-flexible coupling dynamic theory, this article took the frame and the spring as the spatial flexible body, used the UA tire model, considered the engine ...
Xiang Han
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Solution of inverse geometrico-static problem (IGP) for suspended rigid-flexible coupling parallel mechanism (RFCPM) driven by elastic thin rods [PDF]

Mechanical Sciences
Rigid-flexible coupling is the development trend of lightweight parallel mechanisms. Different from traditional rigid parallel mechanisms, although the flexible components are light in weight, the large elastic deformation generated by the mechanism will
J. Chen, Y. Wen, D. Liang, J. Liang, C. Song, C. Song, J. Mo   +6 more
doaj   +1 more source

Coupling between flexible ship and liquid sloshing using potential flow analysis

, 2010
The significant increase in demand for Liquefied Natural Gas (LNG) and the economic aspects of its transportation resulted in increases in the number and size of LNG carriers.
Temarel, Pandeli, Lee, Youngbum, Miao, Shihua, Tan, Mingyi   +3 more
core   +2 more sources

Rigid-flexible coupling modeling of the dual-rotor system for aero-engine [PDF]

, 2023
The dual-rotor system is the core component of advanced aero-engine. Establishing a reasonable, accurate, and efficient dynamics model is the key to studying the dynamics and vibration of the rotor system for aero-engine.
Dong, Yuehui, Liu, Muge, Zhao, Hangqi, Ma, Pingping, Li, Yang   +4 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Rigid-Flexible Coupling Dynamics Analysis of Clock Mechanism

, 2010
As a device for time-delay, clock mechanism is widely used in fuze safety and arming device, whose core component is the runaway escapement. With the development of artillery systems, the dynamic environment during the projectile becomes more and more ...
Geng Chen Shi, Li Sui, Wei Song, Ping Song   +3 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source