Results 41 to 50 of about 194,357 (268)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Quantitative Measurement of Rigidity in Parkinson’s Disease: A Systematic Review
Sensors, 2020 Rigidity is one of the cardinal symptoms of Parkinson’s disease (PD). Present in up 89% of cases, it is typically assessed with clinical scales. However, these instruments show limitations due to their subjectivity and poor intra- and inter-rater ...
María del Rosario Ferreira-Sánchez +2 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
International Journal of Applied Mechanics and Engineering, 2018 The present paper studies the effect of circular regularity on propagation of torsional surface waves in an elastic non-homogeneous half-space. Both rigidity and density of the half-space are assumed to vary inversely linearly with depth.
M. Sethi, A.K. Sharma, A. Sharma
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α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Железобетонные конструкции, 2023 In the practice of modern construction, flexible centrally and eccentrically compressed reinforced concrete elements are becoming more common. In this regard, the relevance of studying their work and the mechanism of bearing capacity exhaustion increases.
A. G. Tamrazyan
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Rigidity controllable as-rigid-as-possible shape deformation [PDF]
Graphical Models, 2017 Shape deformation is one of the fundamental techniques in geometric processing. One principle of deformation is to preserve the geometric details while distributing the necessary distortions uniformly. To achieve this, state-of-the-art techniques deform shapes in a locally as-rigid-as-possible (ARAP) manner.
Shu-Yu Chen +3 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Наука и техника, 2015 FEM-analysis of dynamics in the bearing system of a heavy-duty machine tool has been carried out in the paper. This is a prospective variant for a large-size multi-purpose machine tool with a horizontal sliding ram.
Yu. V. Vasilevich +3 more
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