Results 51 to 60 of about 194,357 (268)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

RESONANCE BEHAVIOUR ANALYSIS OF CARRYING SYSTEM IN HEAVY MACHINE WITH TRAVELING-COLUMN

Наука и техника, 2015
A finite elements method (FEM)-analysis has been carried out with the purpose to study dynamics of carrying system in a machine tool of unique height.
Yu. V. Vasilevich, S. S. Dovnar
doaj  

Charge-transport properties of 4-(1,2,2-triphenylvinyl)aniline salicylaldehyde hydrazone: tight-packing induced molecular `hardening'

IUCrJ, 2017
Based on first-principles calculations, the relationship between molecular packing and charge-transport parameters has been investigated and analysed in detail.
Huipeng Ma, Shuo Chai, Dengyi Chen, Jin-Dou Huang   +3 more
doaj   +1 more source

On Horospherical Rigidity

International Mathematics Research Notices
Abstract We prove that on a closed negatively curved manifold of dimension greater than two, a horosphere endowed with the induced Riemannian metric cannot have non-negative scalar curvature unless the manifold is real hyperbolic, in which case all horospheres are flat.
Besson, Gérard, Courtois, Gilles, Hersonsky, Sa'ar   +2 more
openaire   +2 more sources

On affine rigidity

CoRR, 2010
We study the properties of affine rigidity of a hypergraph and prove a variety of fundamental results. First, we show that affine rigidity is a generic property (i.e., depends only on the hypergraph, not the particular embedding). Then we prove that a graph is generically neighborhood affinely rigid in d-dimensional space if it is (d+1)-vertex ...
Steven J. Gortler, Craig Gotsman, Ligang Liu 0001, Dylan Thurston   +3 more
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Rigidity of packings

European Journal of Combinatorics, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Rigidity of Holomorphically Projective Mappings of Kähler Spaces with Finite Complete Geodesics

Mathematics
In this work, we consider holomorphically projective mappings of (pseudo-) Kähler spaces. We determine the conditions for finite complete geodesics that must be satisfied for the mappings to be trivial; i.e., these spaces are rigid.
Lenka Vítková, Irena Hinterleitner, Josef Mikeš   +2 more
doaj   +1 more source

Cognitive Remediation Therapy for Adolescents with Anorexia Nervosa—Treatment Satisfaction and the Perception of Change

Behavioral Sciences, 2017
Cognitive remediation therapy (CRT) has recently been developed for children and adolescents with anorexia nervosa (AN). It focuses on decreasing rigid cognitions and behaviors, as well as increasing central coherence.
Camilla Lindvall Dahlgren, Kristin Stedal   +1 more
doaj   +1 more source