Results 71 to 80 of about 1,327 (186)

Anti-migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice [PDF]

, 2020
Objective: Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRPmediated vasodilation is, however, a critical rescue mechanism in ischemia.
Ayata, C., Danser, A.H.J. (Jan), de Vries, T., Ferrari, M.D. (Michel), Li, M. (Minghui), Maagdenberg, A.M.J.M. (Arn), Maassen van den Brink, A. (Antoinette), Mulder, I.A., Qin, T., Sugimoto, K., van den Bogaerdt, A., Wermer, M.J.H. (Marieke), Yanagisawa, T.   +12 more
core   +2 more sources

The International Pediatric Headache Didactic Series: A Novel Curriculum Innovation

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 793-800, April 2026.
Abstract Objectives The International Pediatric Headache Didactic Series (IPHDS) was developed to provide free, comprehensive pediatric headache education to healthcare professionals worldwide. The objective of this study was to describe the design, implementation, and impact of this prospective educational intervention. Background Headache is the most
Sara Pavitt, Sruthi Ilangovan, Zoë Allen, Samantha L. Irwin, Irene Patniyot   +4 more
wiley   +1 more source

Pharmacology of erenumab in human isolated coronary and meningeal arteries:Additional effect of gepants on top of a maximum effect of erenumab [PDF]

Background and Purpose: Multiple drugs targeting the calcitonin gene-related peptide (CGRP) receptor have been developed for migraine treatment. Here, the effect of the monoclonal antibody erenumab on CGRP-induced vasorelaxation was investigated in human
Bussiere, Jeanine, Dammers, Ruben, Danser, A. H.Jan, de Vries, Tessa, MaassenVanDenBrink, Antoinette, Rubio-Beltrán, Eloísa, Snellman, Josefin, van den Bogaerdt, Antoon   +7 more
core   +1 more source

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
The molecular mechanism for mulberrin regulating lipid metabolism homeostasis. ABSTRACT Lipid metabolism disorders and the induced metabolic diseases have risen to become one of the primary public health issues. Our preliminary experimental results confirmed that mulberry leaf flavonoid extract exhibited efficacy in lipid metabolism regulation; the ...
Qian Li, Daorui Pang, Erna Li, Dongxu Xing, Fan Liu, Li Wang, Yuxiao Zou   +6 more
wiley   +1 more source

Comparative efficacy, safety, and number needed to treat analysis of atogepant and rimegepant for the preventive treatment of episodic migraine in Japanese participants: An indirect comparison analysis

Cephalalgia Reports
Background In the absence of head-to-head analyses, indirect treatment comparisons (ITCs) can be used for comparative treatment evaluations. A previous ITC of atogepant and rimegepant assessed outcomes from US trials for the preventive treatment of ...
Takao Takeshima, Yasuhiko Matsumori, Gina Ahmadyar, Pranav Gandhi, Kari Kelton, Toru Yamazaki, Karen Carr, Krisztian Nagy, Jessica Ailani   +8 more
doaj   +1 more source

Relationship Between Gut Microbiota and Cancer Neuro‐Immunity

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
Tumour cells influence neural activity and microbiota homeostasis through cytokines and immune modulation. Meanwhile, gut microbiota regulates neural function through metabolic products, affects immune responses via neurotransmitters, feedback regulates neural activity and influences tumour microenvironment.
Danyang Wang, Ruirui Cui, Chang You, Wanlin Zheng, Luyao Wang, Yingqi Yang, Hongkai Yu, Bota Cui   +7 more
wiley   +1 more source

Real-World Open-Label Experience with Rimegepant for the Acute Treatment of Migraine Attacks: A Multicenter Pilot Study

Brain Sciences
Objectives: The present open-label multicenter pilot study sought to prospectively evaluate the efficacy and safety of rimegepant in treating migraine attacks.
Emmanouil V. Dermitzakis, Dimitrios Rikos, Michail Vikelis, Georgia Xiromerisiou, Styliani Zisopoulou, Dimitrios Rallis, Panagiotis Soldatos, George S. Vlachos, Georgios G. Vasiliadis, Andreas A. Argyriou   +9 more
doaj   +1 more source

Network Meta-Analysis of Calcitonin Gene-Related Peptide Receptor Antagonists for the Acute Treatment of Migraine

Frontiers in Pharmacology, 2019
Background: Research has indicated that calcitonin gene-related peptide (CGRP) receptor antagonists can be effective in the acute treatment of migraine. Six major drugs are included within this category: telcagepant, olcegepant, BI 44370, rimegepant (BMS-
Fang Xu, Wenjun Sun
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Comparative effects of drug interventions for the acute management of migraine episodes in adults: systematic review and network meta-analysis [PDF]

Objective: To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults. Design: Systematic review and network meta-analysis.
Al-Khazali, Haidar M, Ashina, Håkan, Ashina, Messoud, Christensen, Rune H, Cipriani, Andrea, Deligianni, Christina I, Diener, Hans-Christoph, Karlsson, William K, Kokoti, Lili, Ostinelli, Edoardo G, Ruiz de la Torre, Elena, Tomlinson, Anneka, Zhuang, Zixuan A   +12 more
core   +2 more sources