Results 151 to 160 of about 6,428 (208)

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay. [PDF]

Front Pharmacol
Borrega-Roman L, Hoare BL, Kosar M, Sarott RC, Patej KJ, Bouma J, Scott-Dennis M, Koers EJ, Gazzi T, Mach L, Barrondo S, Sallés J, Guba W, Kusznir E, Nazaré M, Rufer AC, Grether U, Heitman LH, Carreira EM, Sykes DA, Veprintsev DB.   +20 more
europepmc   +1 more source

Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction. [PDF]

J Biomed Sci
Chung DJ, Chen SP, Liu WH, Liu CY, Su NW, Hsu C, Tsai HY, Yang KC, Wu CK, Lin SW, Shie JJ, Zhao MT, Wei TT.   +12 more
europepmc   +1 more source

Targeting cannabinoid receptor 1 for antagonism in pro-fibrotic alveolar macrophages mitigates pulmonary fibrosis. [PDF]

JCI Insight
Basu A, Arif M, Wolf KM, Behee M, Johnson N, Pommerolle L, Pineda RH, Sembrat J, Zawatsky CN, Dvorácskó S, Coffey NJ, Park JK, Karagoz SB, Godlewski G, Jourdan T, Harvey-White J, Königshoff M, Iyer MR, Cinar R.   +18 more
europepmc   +1 more source

Microglial adenosine A_2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors. [PDF]

Front Pharmacol
Cao Y, Wu Z, Zhang M, Ji R, Zhang H, Song L.   +5 more
europepmc   +1 more source

Nicotine replacement therapy: insights into the mechanisms and potential of nicotine receptor pathway. [PDF]

Am J Transl Res
Patidar N, Navale AM, Parsaila N, Sharma D, Nahar P, Shinde S, Solanki N, Shelke A.   +7 more
europepmc   +1 more source

Light-Controlled Modulation of the Endocannabinoid System: Photoswitchable Ligands for Cannabinoid and TRPV1 Receptors. [PDF]

Int J Mol Sci
Corallo AA, Noli C, Brizzi A, Paolino M, Mugnaini C, Corelli F.   +5 more
europepmc   +1 more source

Rimonabant for the Treatment of Obesity

Recent Patents on Cardiovascular Drug Discovery, 2008
Obesity is a growing public health problem that is already reaching epidemic proportions and is increasingly encompassing young children and adolescents. Despite the increasing prevalence and the health risks associated with obesity, the pharmacotherapeutic options for treating obesity are limited. The endogenous cannabinoid or endocan-nabinoid system (
Ashish, Samat, Brian, Tomlinson, Shahrad, Taheri, G Neil, Thomas   +3 more
openaire   +3 more sources