FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Asymmetric ring contraction of 2-hydroxypyranones by borrowing hydrogen biocatalysis. [PDF]
Chem SciLiu Y, O'Connell A, Rolfes JD, Deska J.
europepmc +1 more source
Photochemical Reactions of Aromatic Compounds. XLVI. Stereochemical Reaction Courses in the Photolytic Ring-Cleavage Reactions of Diarylcyclobutanes: Implications of Conformation-Controlled Orbital Interactions in the Excited-State Chemistry [PDF]
, 1989 Chyongjin Pac +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Exploring Regioisomeric Indole-Furanone Tubulin Inhibitors. [PDF]
ACS OmegaVenettozzi M +14 more
europepmc +1 more source
Interdisciplinary study of Gulf Stream warm core ring physics, chemistry, and biology : report of the Warm Core Rings Data Workshop, July 6-19, 1983, Whispering Pines Conference Center, W. Alton Jones Campus, University of Rhode Island, West Greenwich, Rhode Island [PDF]
, 1983 Peter H. Wiebe
openalex +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Macrocyclic Ruthenium Ring Expansion Metathesis Polymerization Initiators Exhibit Tether Length-Dependent Behavior. [PDF]
OrganometallicsPomfret MN +10 more
europepmc +1 more source
Warm core rings : an interdisciplinary study of warm core ring physics, chemistry, and biology; R/V Endeavor, R/V Atlantis II September/October 1981 cruise reports [PDF]
, 1981 Terrence M. Joyce, Peter H. Wiebe
openalex +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source