Results 21 to 30 of about 284,604 (310)
A Farewell Symposium to the Retiring Professors Catherine E. Housecroft and Edwin C. Constable
CHIMIA, 2023 On the 5th of May 2023, the Department of Chemistry at the University of Basel celebrated the careers of their long-term colleagues Catherine E. Housecroft and Edwin C. Constable with a farewell symposium. Seven former coworkers and current colleagues of
Murielle F. Delley, Oliver S. Wenger
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NeoPHOX – a structurally tunable ligand system for asymmetric catalysis
Beilstein Journal of Organic Chemistry, 2016 A synthesis of new NeoPHOX ligands derived from serine or threonine has been developed. The central intermediate is a NeoPHOX derivative bearing a methoxycarbonyl group at the stereogenic center next to the oxazoline N atom.
Jaroslav Padevět +3 more
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Biosensors, 2021 Biofilms growing on electrodes are the heart piece of bioelectrochemical systems (BES). Moreover, the biofilm morphology is key for the efficient performance of BES and must be monitored and controlled for a stable operation.
Andreas Netsch +2 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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Label‐Free Fluorescent Kinase and Phosphatase Enzyme Assays with Supramolecular Host‐Dye Pairs
ChemistryOpen, 2019 The combination of the macrocyclic hosts p‐sulfonatocalix[4]arene and cucurbit[7]uril with the fluorescent dyes lucigenin and berberine affords two label‐free enzyme assays for the detection of kinase and phosphatase activity by fluorescence monitoring ...
Yan‐Cen Liu +4 more
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Recent Biomimetic and Organocatalytic Syntheses of ?-Tocopherol
CHIMIA, 2010 We report here on our efforts to develop new strategies for the synthesis of ?-tocopherol, the biologically most significant member of the vitamin E family.
Antoinette Chougnet +2 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
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DNA Damaging Agents in Chemical Biology and Cancer
CHIMIA, 2020 Despite their toxicity, DNA alkylating drugs remain a cornerstone of anticancer therapy. The classical thinking was that rapidly dividing tumour cells left more of its DNA in an exposed single-stranded state, making these rapidly dividing cells more ...
Basilius Sauter, Dennis Gillingham
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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