Results 41 to 50 of about 859,806 (359)
DNA Damaging Agents in Chemical Biology and Cancer
CHIMIA, 2020 Despite their toxicity, DNA alkylating drugs remain a cornerstone of anticancer therapy. The classical thinking was that rapidly dividing tumour cells left more of its DNA in an exposed single-stranded state, making these rapidly dividing cells more ...
Basilius Sauter, Dennis Gillingham
doaj +1 more source
Put a ring on it: application of small aliphatic rings in medicinal chemistry
RSC Medicinal Chemistry, 2021 Aliphatic small rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry. This review summarises judicious successful application and reported limitations of these ring systems.
Matthias R. Bauer +6 more
openaire +3 more sources
Lithiation of 4-membered heterocycles as useful strategy for the preparation of new molecular scaffolds: addressing the regioselectivity in azetidines and thietanes [PDF]
, 2013 Four-membered heterocycles (4-MH) with one or two heteroatoms are of great importance in medicinal chemistry and synthetic organic chemistry. This kind of scaffolds show peculiar structural features, related to the ring “puckering”, and biological ...
Carroccia, Laura +7 more
core
Kinetic and Thermodynamic Approaches for the Efficient Formation of Mechanical Bonds [PDF]
, 2008 Among the growing collection of molecular systems under consideration for nanoscale device applications, mechanically interlocked compounds derived from electrochemically switchable bistable [2]rotaxanes and [2]catenanes show great promise. These systems
Aprahamian, Ivan +7 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Recent Biomimetic and Organocatalytic Syntheses of ?-Tocopherol
CHIMIA, 2010 We report here on our efforts to develop new strategies for the synthesis of ?-tocopherol, the biologically most significant member of the vitamin E family.
Antoinette Chougnet +2 more
doaj +1 more source
Effect of the superconducting wiggler on the DELSY beam dynamics
, 2003 The project DELSY is being under development at JINR, Dubna, Russia. This synchrotron radiation source is dedicated to the investigation on condensed matter physics, atomic physics, biology, medicine, chemistry, micromechanics, lithography and others ...
Ando +5 more
core +1 more source
Spiers Memorial Lecture: Molecular mechanics and molecular electronics [PDF]
, 2006 We describe our research into building integrated molecular electronics circuitry for a diverse set of functions, and with a focus on the fundamental scientific issues that surround this project.
Beckman, Robert +11 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Hydrogen bond network topology in liquid water and methanol: a graph theory approach [PDF]
, 2013 Networks are increasingly recognized as important building blocks of various systems in nature and society. Water is known to possess an extended hydrogen bond network, in which the individual bonds are broken in the sub-picosecond range and still the ...
Abascal +68 more
core +1 more source