Results 141 to 150 of about 938,190 (242)
Ring-Closing Metathesis on Commercial Scale: Synthesis of HCV Protease Inhibitor Simeprevir
, 2019 The key macrocyclization step in the synthesis of simeprevir, a hepatitis C virus (HCV) antiviral drug, was studied. N-Boc substitution on the diene precursor changes the site of insertion of the metathesis catalyst and, consequently, the kinetic model ...
Dirk Van Den Heuvel (6369197) +17 more
core +1 more source
Macromolecular Rapid Communications, Volume 47, Issue 21, 6 November 2026.High‐performance 1,3,5‐triazine epoxy networks are prepared via solvent‐free curing and recycled using nucleophilic aromatic substitution (SNAr) chemistry. This robust thermoset undergoes clean depolymerization into well‐defined building blocks for seamless repolymerization, achieving chemical recycling while preserving thermomechanical performance ...
Yi‐Ru Chen +3 more
wiley +1 more source
Design, synthesis and photophysical properties of novel star-shaped truxene-based heterocycles utilizing ring-closing metathesis, Clauson-Kaas, Van Leusen and Ullmann-type reactions as key tools. [PDF]
Beilstein J Org Chem, 2021 Alvi S, Ali R.
europepmc +1 more source
, 2016 The use of ring-opening metathesis (ROM) oligomers as soluble supports for a multistep reaction sequence is described. A Mitsunobu reaction followed by an in situ ROMP-mediated phase-trafficking purification is utilized to generate soluble ROM oligomers ...
Andrew M. Harned (1490518) +3 more
core +1 more source
Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.Proton‑transfer catalysis controls acylsemicarbazide dissociation, linking proton affinity to exchange kinetics and enabling predictive design of robust, tunable dynamic covalent networks. ABSTRACT We provide design principles for predicting bond exchange kinetics in acylsemicarbazide (ASC)‐based systems that can be applied to tuning the properties of ...
Siebe Lekanne Deprez +6 more
wiley +1 more source
Dual Activity of Grubbs-Type Catalyst in the Transvinylation of Carboxylic Acids and Ring-Closing Metathesis Reactions. [PDF]
J Org Chem, 2020 Brodzka A, Koszelewski D, Ostaszewski R.
europepmc +1 more source
, 2016 Catalyzed by the first-generation Grubbs’ ruthenium complex, tandem intramolecular/intermolecular metathesis of 1,6-enynes bearing a cyclopropene ring took place smoothly to produce 3-pyrroline derivatives in satisfactory yields via ring-opening/ring ...
Min Shi (141075), Zhi-Bin Zhu (2231500)
core +1 more source
Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.Five heteroleptic iridium(III) complexes bearing cyclometalated 2,4‐diphenylpyridinato ligands were synthesized and their electrochemiluminescence (ECL) investigated. Two different coreactants were evaluated: tri‐n‐propylamine and benzoyl peroxide under anodic and cathodic potentials, respectively.
Ovini Jayawardana +6 more
wiley +1 more source
Modular and Stereoselective Synthesis of Cyclobutane β‐Amino Alcohols
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.Late‐stage functionalization and photoisomerization of 1,2‐azaborine leads to a general strategy for the synthesis of diversely substituted cyclobutane β‐amino alcohols. The relative stereochemistry of the resulting products is unambiguously defined by the stereospecific and stereoselective nature of the photoisomerization‐hydrogenation‐oxidation ...
Xinyu Yang +3 more
wiley +2 more sources
Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source