Results 51 to 60 of about 395,689 (219)

Residuals to the CHAOS‐6 Geomagnetic Field Model Caused by Magnetospheric Currents During Enhanced Magnetic Activity

Geochemistry, Geophysics, Geosystems, 2020
Thanks to mapping missions, like Ørsted, CHAMP, and Swarm, we have gained a detailed understanding of the geomagnetic field. High‐resolution models like POMME, GRIMM, or CHAOS are able to describe the main parts of the Earth's magnetic field reliably ...
Hermann Lühr, Yun‐Liang Zhou
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Geomagnetic response to solar and interplanetary disturbances

Journal of Space Weather and Space Climate, 2013
The space weather discipline involves different physical scenarios, which are characterised by very different physical conditions, ranging from the Sun to the terrestrial magnetosphere and ionosphere.
Saiz Elena, Cerrato Yolanda, Cid Consuelo, Dobrica Venera, Hejda Pavel, Nenovski Petko, Stauning Peter, Bochnicek Josef, Danov Dimitar, Demetrescu Crisan, Gonzalez Walter D., Maris Georgeta, Teodosiev Dimitar, Valach Fridich   +13 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Storm Time Plasma Pressure Inferred From Multimission Measurements and Its Validation Using Van Allen Probes Particle Data

Space Weather, 2020
The k‐nearest‐neighbor technique is used to mine a multimission magnetometer database for a subset of data points from time intervals that are similar to the storm state of the magnetosphere for a particular moment in time. These subsets of data are then
G. K. Stephens, S. T. Bingham, M. I. Sitnov, M. Gkioulidou, V. G. Merkin, H. Korth, N. A. Tsyganenko, A. Y. Ukhorskiy   +7 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Statistical Properties of Molecular Ions in the Ring Current Observed by the Arase (ERG) Satellite

Geophysical Research Letters, 2019
Molecular ions in the magnetosphere can be a tracer of fast ion outflows from the deep ionosphere. Statistical properties of molecular ions (O2+/NO+/N2+) in the ring current are investigated based on ion composition measurements (
K. Seki, K. Keika, S. Kasahara, S. Yokota, T. Hori, K. Asamura, N. Higashio, M. Takada, Y. Ogawa, A. Matsuoka, M. Teramoto, Y. Miyoshi, I. Shinohara   +12 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source