Results 161 to 170 of about 830,676 (348)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Correction to “Carbodiimide Ring-Opening Metathesis Polymerization”

ACS Central Science, 2023
J. Drake Johnson, Samuel W. Kaplan, Jozsef Toth, Zian Wang, Mitchell Maw, Sergei S. Sheiko, Aleksandr V. Zhukhovitskiy   +6 more
doaj   +1 more source

Analysis of radially cracked ring segments subject to forces and couples [PDF]

Results of planar boundary collocation analysis are given for ring segment (C shaped) specimens with radial cracks, subjected to combined forces and couples. Mode I stress intensity factors and crack mouth opening displacements were determined for ratios
Gross, B., Strawley, J. E.
core   +1 more source

Lipase/esterase-catalyzed ring-opening polymerization: A green polyester synthesis technique

, 2011
Yan Yang, Yang Yu, Yuanxin Zhang, Chengbai Liu, Wei Shi, Quanshun Li   +5 more
openalex   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Influence of the Ir content and the support on the thiotolerance of the Ir/SiO₂‐Al₂O₃ catalysts for selective ring opening of decalin [PDF]

, 2020
Silvana A. D’Ippolito, Adriana Ballarini, Santiago M. Rosas, Laurence Pirault‐Roy, Catherine Especel, Florence Epron, Carlos L. Pieck   +6 more
openalex   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Ring-Opening of Aziridines Using Tethered Hemiketals. [PDF]

J Org Chem
Silver R, Manna A, Kelley SP, Sathyamoorthi S.   +3 more
europepmc   +1 more source

Photochemical ring-opening in 20-chloro-chlorophylls [PDF]

, 1990
D Dörnemann, D Dörnemann, GAF Hendry, H Brockmann Jr., H Fischer, H Scheer, H. P. Isenring, J Fajer, J-H Fuhrhop, J-H Fuhrhop, M Kobayashi, M Senge, M Senge, MS Huster, O Shimomura, PH Hynninen, PM Champion, RB Woodward, RE Moore, SB Brown, Scheer, T Katoh, T Watanabe, W Rüdiger   +23 more
core   +1 more source

Synthesis of 8‐amino‐4‐methylthio‐6‐methyl‐2‐(β‐D‐ribofuranosyl)‐2,6‐dihydro‐1,2,3,5,6,7‐hexaazaacenaphthylene and an unusual reductive ring‐opening of the 1,2,3,5,6,7‐hexaazaacenaphthylene ring system [PDF]

, 1991
Andrew M. Kawasaki, Leroy B. Townsend
openalex   +1 more source