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Preface to “Aziridine Chemistry” [PDF]
Molecules, 2021 Aziridine is a nitrogen-containing three-membered ring with similar ring strain energy as other three-membered ring compounds, including cyclopropane and oxirane [...]
Hyun-Joon Ha
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Mechanistic Insights into Lewis Acid-Catalyzed Formal [3 + 2] Cycloadditions of Aziridines: A Molecular Electron Density Theory Study [PDF]
MoleculesThe Lewis acid (LA)-promoted formal [3 + 2] cycloaddition (32CA) reaction of 2-phenyl-1-tosylaziridine (2PTA) with ketone has been studied within the framework of Molecular Electron Density Theory (MEDT) at the ωB97X-D/6-311G(d,p) computational level in ...
Luis R. Domingo +2 more
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Adapting Bower's intramolecular aziridination reaction allows for a metal-free synthesis of N-H aziridines. [PDF]
Org Biomol ChemSilver R, Kelley SP, Sathyamoorthi S.
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Salen–scandium(III) complex-catalyzed asymmetric (3 + 2) annulation of aziridines and aldehydes [PDF]
Beilstein Journal of Organic ChemistryOxazolidine is one of the crucial structural moieties of biologically active compounds. A salen–scandium triflate complex-catalyzed asymmetric (3 + 2) annulation of dialkyl 1-sulfonylaziridine-2,2-dicarboxylates and aldehydes generated optically active ...
Linqiang Wang, Jiaxi Xu
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Regioselective ring opening of aziridine for synthesizing azaheterocycle
Frontiers in Chemistry, 2023 Aziridine had different regioselective ring openings depending on the functional group of its alkyl substituent. In the case of the alkyl group bearing γ-ketone at the C2 substituent of aziridine, the ring opening by the hydroxy nucleophile from H2O ...
Nikhil Srivastava, Hyun-Joon Ha
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Pd-Catalyzed Cycloaddition of Bicyclic Aziridine with Isocyanates
Medical Sciences Forum, 2022 Nitrogen-containing heterocycles can have several applications in the pharmaceutical industry since they contain a wide spectrum of biological activities. Imidazolidinones have shown activity against leukemia, lung cancer, and metabolic disorders.
Mariana Crespo Monteiro +2 more
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Frontiers in Chemistry, 2023 Herein we report a copper-catalyzed synthesis of imidazolidine by employing the reaction of aziridine with imine. The reaction smoothly provided a diverse range of 2-substituted imidazolidines with high compatibility with various functional groups ...
Kota Hashimoto +4 more
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Alkylative Aziridine Ring-Opening Reactions
Molecules, 2021 In this study, the highly strained three-membered aziridine ring was successfully activated as the aziridinium ion by alkylation of the ring nitrogen with a methyl, ethyl or allyl group, which was followed by ring opening with external nucleophiles such ...
Jieun Choi, Taehwan Yu, Hyun-Joon Ha
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The Synthesis of (2R)-Aziridine-2-carboxylic Acid Containing Dipeptides
Acta Chimica Slovenica, 2022 Optimized conditions for the synthesis of fully deprotected (2R)-aziridine containing dipeptides are described. Preparation of fully protected N- and C- terminal aziridine containing dipeptides was found to be straightforward and high yielding for the ...
Samo Kuzmič, Martina Hrast, Rok Frlan
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N-Carbomethoxy Aziridines. [PDF]
Acta Chemica Scandinavica, 1972 Tyge Greibrokk +4 more
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