Results 1 to 10 of about 4,788 (165)
Preface to “Aziridine Chemistry” [PDF]
Molecules, 2021 Aziridine is a nitrogen-containing three-membered ring with similar ring strain energy as other three-membered ring compounds, including cyclopropane and oxirane [...]
Hyun-Joon Ha
doaj +3 more sources
Regioselective ring opening of aziridine for synthesizing azaheterocycle
Frontiers in Chemistry, 2023 Aziridine had different regioselective ring openings depending on the functional group of its alkyl substituent. In the case of the alkyl group bearing γ-ketone at the C2 substituent of aziridine, the ring opening by the hydroxy nucleophile from H2O ...
Hyun-Joon Ha, Ha Hyun-Joon
exaly +3 more sources
Mechanistic Insights into Lewis Acid-Catalyzed Formal [3 + 2] Cycloadditions of Aziridines: A Molecular Electron Density Theory Study [PDF]
MoleculesThe Lewis acid (LA)-promoted formal [3 + 2] cycloaddition (32CA) reaction of 2-phenyl-1-tosylaziridine (2PTA) with ketone has been studied within the framework of Molecular Electron Density Theory (MEDT) at the ωB97X-D/6-311G(d,p) computational level in ...
Luis R. Domingo +2 more
doaj +2 more sources
Pd-Catalyzed Cycloaddition of Bicyclic Aziridine with Isocyanates
Medical Sciences Forum, 2022 Nitrogen-containing heterocycles can have several applications in the pharmaceutical industry since they contain a wide spectrum of biological activities. Imidazolidinones have shown activity against leukemia, lung cancer, and metabolic disorders.
Mariana Crespo Monteiro +2 more
doaj +1 more source
Frontiers in Chemistry, 2023 Herein we report a copper-catalyzed synthesis of imidazolidine by employing the reaction of aziridine with imine. The reaction smoothly provided a diverse range of 2-substituted imidazolidines with high compatibility with various functional groups ...
Kota Hashimoto +4 more
doaj +1 more source
Substituted Aziridines by Lithiation—Electrophile Trapping of Terminal Aziridines. [PDF]
ChemInform, 2005 AbstractFor Abstract see ChemInform Abstract in Full Text.
Hodgson, D, Humphreys, P, Ward, J
openaire +3 more sources
Alkylative Aziridine Ring-Opening Reactions
Molecules, 2021 In this study, the highly strained three-membered aziridine ring was successfully activated as the aziridinium ion by alkylation of the ring nitrogen with a methyl, ethyl or allyl group, which was followed by ring opening with external nucleophiles such ...
Jieun Choi, Taehwan Yu, Hyun-Joon Ha
doaj +1 more source
The Synthesis of (2R)-Aziridine-2-carboxylic Acid Containing Dipeptides
Acta Chimica Slovenica, 2022 Optimized conditions for the synthesis of fully deprotected (2R)-aziridine containing dipeptides are described. Preparation of fully protected N- and C- terminal aziridine containing dipeptides was found to be straightforward and high yielding for the ...
Samo Kuzmič, Martina Hrast, Rok Frlan
doaj +1 more source
Molecules, 2022 Endophytes, being the co-evolution partners of green host plants, are factories of pharmaceutically valuable novel natural products. Cochliobolus sp. APS1, an endophyte of Andrographis paniculata (Green Chiretta), produces a plethora of natural bioactive
Hiran Kanti Santra +2 more
doaj +1 more source
Molecules, 2021 Aziridine derivatives involved in nucleophilic ring-opening reactions have attracted great interest, since they allow the preparation of biologically active molecules.
Valentina Verdoliva +3 more
doaj +1 more source