Molecules, 2023 The efficient one-pot halofluorination of a β-enaminophosphonate/β-iminophosphonate tautomeric mixture resulting in α,α-halofluorinated β-iminophosphonates is reported.
Mateusz Klarek +4 more
doaj +1 more source
Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ [PDF]
, 1990 2,5-Bis(1-aziridinyl)-1,4-benzoquinone (BABQ) is a compound from which several antitumour drugs are derived, such as Trenimone, Carboquone and Diaziquone (AZQ).
Egberink, Richard J.M. +5 more
core +2 more sources
Crystal structure of 1-[(2,4,6-triisopropylphenyl)sulfonyl]aziridine
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C17H27NO2S, exhibits a distorted geometry of the aromatic ring with elongated bonds at the ipso-C atom. The S atom deviates from the aromatic ring plane by 0.393 (4) Å.
Lena Knauer +2 more
doaj +1 more source
In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside
Biomedicines, 2021 We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-β-D-galactopyranoside (AzGalp ...
Estefanía Burgos-Morón +10 more
doaj +1 more source
N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds
Beilstein Journal of Organic Chemistry, 2019 Since Garner’s aldehyde has several drawbacks, first of all is prone to racemization, alternative three-carbon chirons would be of great value in enantioselective syntheses of natural compounds and/or drugs. This review article summarizes applications of
Iwona E. Głowacka +3 more
doaj +1 more source
Molecules, 2022 A short synthetic route to stereoselective access to C-glycosyl-aminoethyl sulfide derivatives has been developed through the reaction of tributhyltin derivatives of glycals with aziridinecarboaldehyde and the regioselective ring opening of a chiral ...
Aleksandra Tracz +3 more
doaj +1 more source
A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance [PDF]
, 2010 Background: Acquired resistance to glucocorticoids constitutes a major clinical challenge, often overlooked in the search for improved alternatives to classic steroids.
De Bosscher, Karolien +5 more
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Aziridinierung eines einzelnen Kohlenstoffatoms in Alkenen mittels Energietransferkatalyse
Angewandte Chemie, EarlyView.Im Gegensatz zur traditionellen Alken‐Aziridinierung über (formalen) Nitren‐Transfer berichten wir hier über eine Strategie zur intermolekularen Aziridinierung eines einzelnen Alken‐Kohlenstoffatoms bei zusätzlicher Funktionalisierung der anderen Position. Durch Energietransfer‐ (EnT‐)Katalyse werden Alkenylboronate und ‐silane in reaktive Intermediate
Fritz Paulus +7 more
wiley +1 more source
Aziridine-Metathesis based Approaches to Alkaloid Synthesis [PDF]
, 2009 The aim of the project is to synthesise (-)-morphine utilising aziridine and metathesischemistry. The thesis is divided into three chapters.Chapter 1 provides brief reviews on the subjects of total synthesis of morphine; ringrearrangementmetathesis (RRM)
Lu, Pengfei, Lu, Pengfei
core
Recent advances in the total synthesis of agelastatins [PDF]
, 2010 Agelastatins represent an important family of marine alkaloids in terms of both exceptional biological activity and intriguing chemical structure.
Dong, Guangbin
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