Results 41 to 50 of about 8,858 (221)

Functionalized 1,3,5-triazine-derivatives as promising anticancer agents: synthesis and cytotoxic activity in vitro

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Introduction. A promising area of application of 1,3,5-triazines in medical chemistry is the development of highly effective anticancer agents. It is noteworthy that a significant cytotoxic effect may occur with 2,4,6-substituted 1,3,5-triazine ...
A. V. Protas, O. V. Mikolaichuk, E. A. Popova, K. V. Timoshchuk, D. N. Maistrenko, O. E. Molchanov, V. V. Sharoyko, K. N. Semenov   +7 more
doaj   +1 more source

Synthesis of the key aziridine intermediate 12 and aziridine opening reaction.

, 2018
Synthesis of the key aziridine intermediate 12 and aziridine opening reaction.
Črtomir Podlipnik (4899181), Masahiro Niikura (1891927), Cinzia Colombo (165760), Leonardo Lo Presti (1367703), Andrew J. Bennet (1755919), Anna Bernardi (1703314)   +5 more
core   +1 more source

Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine

Compounds
The smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added ...
Partha Sarathi Bera, Yafia Kousin Mirza, Tarunika Sachdeva, Milan Bera   +3 more
doaj   +1 more source

Synthesis of chiral N-phosphoryl aziridines through enantioselective aziridination of alkenes with phosphoryl azide via Co(II)-based metalloradical catalysis

Beilstein Journal of Organic Chemistry, 2014
The Co(II) complex of a new D2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source.
Jingran Tao, Li-Mei Jin, X. Peter Zhang
doaj   +1 more source

Enzymatic Resolution of Aziridine-Carboxylates

, 1993
N-acyl-aziridine-2-carboxylates and N-acyl-aziridine-2,3-dicarboxylates have been resolved with good to excellent stereochemical purity by enzymatic hydrolysis catalyzed by lipase from Candida ...
BUCCIARELLI, Maria, Giovanni Torre, MORETTI, Irene, Maria Bucciarelli, Irene Moretti, FORNI, Arrigo, TORRE, Giovanni, Fabio Prati, Arrigo Forni, PRATI, Fabio   +9 more
core   +1 more source

Microwave-promoted total synthesis of N-(α-hydroxybenzyl)formamides using DMSO/H2O under neutral conditions

Green Chemistry Letters and Reviews, 2016
A total synthesis route toward N-(α-hydroxybenzyl)formamides by microwave-assisted reaction of dichloroaziridines and aqueous dimethyl sulfoxide is described. The corresponding products were obtained in excellent yields with reduced reaction times.
Khadijeh Rabiei, Hossein Naeimi
doaj   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Y(OTf)₃-Salazin-Catalyzed Asymmetric Aldol Condensation

Molecules
The chiral aziridine-containing vicinal iminophenol tridentate ligands (named salazins) are a class of readily prepared chiral ligands from enantiopure aziridines and salicylaldehydes.
Chengzhuo Wang, Ning Chen, Zhanhui Yang, Jiaxi Xu   +3 more
doaj   +1 more source

A Mild and Regioselective Ring-Opening of Aziridines with Acid Anhydride Using TBD or PS-TBD as a Catalyst

Molecules, 2015
The ring-opening of N-tosylaziridines with various acid anhydrides catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding β-amino esters in excellent yields under mild reaction conditions. Polymer-supported catalyst,
Satoru Matsukawa, Yasutaka Mouri
doaj   +1 more source

Successive Azide and DNA Functionalization for Reversible and Controlled Association of Single‐Wall Carbon Nanotubes

Chemistry – A European Journal, EarlyView.
A newly synthesized bifunctional azide—diazonium linker allows robust one‐step introduction of azido groups to single‐wall carbon nanotubes. Versatility of the azido groups as reactive handles is demonstrated by further derivatization with 6‐carboxyfluorescein and oligonucleotides.
Razieh Moosavi, Tharun K. Kotammagari, Pia Damlin, Mikko Salomäki, Mika Lastusaari, Han Li, Tuomas Lönnberg   +6 more
wiley   +1 more source