Results 31 to 40 of about 7,765 (231)
Crystal structure of 1-[(2,4,6-triisopropylphenyl)sulfonyl]aziridine
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C17H27NO2S, exhibits a distorted geometry of the aromatic ring with elongated bonds at the ipso-C atom. The S atom deviates from the aromatic ring plane by 0.393 (4) Å.
Lena Knauer +2 more
doaj +1 more source
In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside
Biomedicines, 2021 We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-β-D-galactopyranoside (AzGalp ...
Estefanía Burgos-Morón +10 more
doaj +1 more source
Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium
Angewandte Chemie, EarlyView.Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner +2 more
wiley +1 more source
N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds
Beilstein Journal of Organic Chemistry, 2019 Since Garner’s aldehyde has several drawbacks, first of all is prone to racemization, alternative three-carbon chirons would be of great value in enantioselective syntheses of natural compounds and/or drugs. This review article summarizes applications of
Iwona E. Głowacka +3 more
doaj +1 more source
Molecules, 2022 A short synthetic route to stereoselective access to C-glycosyl-aminoethyl sulfide derivatives has been developed through the reaction of tributhyltin derivatives of glycals with aziridinecarboaldehyde and the regioselective ring opening of a chiral ...
Aleksandra Tracz +3 more
doaj +1 more source
Synthesis and Stereoselective Lithiation of Enantiopure 2‐(1‐Aminoalkyl)aziridine–Borane Complexes
, 2004 This work shows that the enantiopure 2-(1-aminoalkyl)aziridine–borane complexes can easily be obtained by two alternative methodologies: either reaction with BF3·Et2O followed by reduction with LiAlH4 or by direct reaction with a solution of BH3 in THF.
José Ramón Suárez +7 more
core +1 more source
DataSheet1_Regioselective ring opening of aziridine for synthesizing azaheterocycle.PDF
, 2023 Aziridine had different regioselective ring openings depending on the functional group of its alkyl substituent. In the case of the alkyl group bearing γ-ketone at the C2 substituent of aziridine, the ring opening by the hydroxy nucleophile from H2O ...
Hyun-Joon Ha (2073736) +1 more
core +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, EarlyView.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
, 1990 Inelastic Neutron Scattering spectrum of Aziridine, C₂H₅N, measured on the TFXA ...
H. Jobic, CNRS Villerneuve
core +1 more source
Molecules, 2016 Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition.
Wen Ren +5 more
doaj +1 more source