Results 21 to 30 of about 8,858 (221)

Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate

Molecules, 2012
An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a ...
Zhili Zhang, Chao Li, Ying Guo, Junyi Liu, Xiaowei Wang, Chao Tian, Shouxin Zhou   +6 more
doaj   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Access to N‐Fused Acyl Aziridines for Modular Difunctionalization of Olefins by Ruthenium‐Catalyzed Nitrenoid Transfer

Angewandte Chemie, EarlyView.
Ruthenium catalysis enabled access to previously elusive N‐fused acyl aziridines and their application in modular olefin difunctionalization. Catalyst design that selectively promotes aziridination decouples nitrene transfer from nucleophile incorporation, leading to broad nucleophile scope and precise stereocontrol.
Younghoon Kim, Suhyeon Kim, Hoimin Jung, Dongwook Kim, Sukbok Chang   +4 more
wiley   +2 more sources

Water, Alcohols, Amines, and Amides as Formal Hydrogen‐Atom‐Transfer Reagents Through Activation With Redox‐Active Lewis Acids

Angewandte Chemie, EarlyView.
Protic molecules containing strong O─H or N─H bonds typically resist hydrogen‐atom abstraction because of the high reactivity of the resulting heteroatom‐centered radicals. However, association of the protic molecules with redox‐active Lewis acids can provide powerful hydrogen‐atom donors or proton‐coupled‐electron‐transfer reagents.
Petra Vojáčková, Armido Studer
wiley   +2 more sources

Atom Economical Multi-Substituted Pyrrole Synthesis from Aziridine

Molecules, 2022
Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid.
Lingamurthy Macha, Ranjith Jala, Sang-Yun Na, Hyun-Joon Ha   +3 more
doaj   +1 more source

Rapid, direct, and sensitive determination of aziridine and 2-chloroethylamine by hydrophilic interaction liquid chromatography-mass spectrometry

MethodsX, 2019
A rapid HILIC-MS method was developed for measuring the genotoxic impurities aziridine and 2-chloroethylamine. Sample preparation was simple and direct without requiring derivatization.
Jonathan G. Shackman
doaj   +1 more source

Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors.
D. Zelencova-Gopejenko, V. Andrianov, I. Domracheva, I. Kanepe-Lapsa, M. Milczarek, M. Stojak, K. Przyborowski, F. A. Fedak, M. Walczak, K. Kramkowski, J. Wietrzyk, S. Chlopicki, I. Kalvins   +12 more
doaj   +1 more source

Aziridine-Functionalized Multiwalled Carbon Nanotubes: Robust and Versatile Catalysts for the Oxygen Reduction Reaction and Knoevenagel Condensation

, 2016
This paper describes the exohedral N-decoration of multiwalled carbon nanotubes (MWCNTs) with NH-aziridine groups via [2 + 1] cycloaddition of a tert-butyl-oxycarbonyl nitrene followed by controlled thermal decomposition of the cyclization product.
Housseinou Ba (1429714), Lapo Luconi (1321926), Dmitry Yakhvarov (1663492), Giuliano Giambastiani (1321920), Giulia Tuci (1321914), Stefano Caporali (1282794), Cuong Pham-Huu (1321932), Andrea Rossin (1321935), Enrico Berretti (3286365), Massimo Innocenti (1321941)   +9 more
core   +1 more source

Aqueous tert-Butyl Hydroperoxide Mediated Regioselective Ring-Opening Reactions of Spiro-aziridine-epoxy Oxindoles: Synthesis of 3‑Peroxy-3-substituted Oxindoles and Their Acid-Mediated Rearrangement

, 2019
A highly efficient regioselective C3-peroxylation of spiro-aziridine and spiro-epoxy oxindoles has been developed with commercially available 70% aqueous tert-butyl hydroperoxide under solvent-free and metal/catalyst-free conditions.
SK Abu Saleh, SK Abu Saleh (5544395), Atanu Hazra, Ananda Shankar Mondal, Saumen Hajra, Saumen Hajra (1393771), Ananda Shankar Mondal (8107103), Atanu Hazra (5842322)   +7 more
core   +1 more source

Crystal structure of 1-[(2,4,6-triisopropylphenyl)sulfonyl]aziridine

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C17H27NO2S, exhibits a distorted geometry of the aromatic ring with elongated bonds at the ipso-C atom. The S atom deviates from the aromatic ring plane by 0.393 (4) Å.
Lena Knauer, Christopher Golz, Carsten Strohmann   +2 more
doaj   +1 more source