Results 51 to 60 of about 17,975 (276)

Aziridination of a Single Carbon Atom in Alkenes via Energy Transfer Catalysis

Angewandte Chemie International Edition, EarlyView.
Contrary to traditional alkene aziridination via (formal) nitrene transfer, we herein report a strategy that achieves intermolecular aziridination of a single alkene carbon atom and installs an additional group at the other. Enabled by metal‐free energy transfer (EnT) catalysis, alkenyl boronates and silanes are transformed into reactive intermediates ...
Fritz Paulus, Corinna Heusel, Felix H. Wessels, Bünyamin Sikora, Maik G. Niedziella, Kilian van der Beck, Constantin G. Daniliuc, Frank Glorius   +7 more
wiley   +1 more source

1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor [PDF]

, 2017
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Aerts, Johannes M.F.G., Artola, Marta, Breen, Imogen Z., Codée, Jeroen D.C., Davies, Gideon J., Ferraz, Maria J., Kuo, Chi Lin, Offen, Wendy A., Overkleeft, Herman S., Raich, Lluís, Rovira, Carme, Van Der Marel, Gijsbert A., Wu, Liang   +12 more
core   +9 more sources

Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole

Molecules, 2016
Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition.
Wen Ren, Qian Zhao, Chuan Zheng, Qiong Zhao, Li Guo, Wei Huang   +5 more
doaj   +1 more source

A cross self-curing system for an aqueous-based PU hybrid [PDF]

, 2005
[[abstract]]Isocyanate (NCO)-terminated polyurethane (PU) prepolymer comprises carboxylic acid, which is obtained from a conventional PU preparation procedure.
Chen, Chen, Chen, Chen, Dieterich, Huang, Kim, Lai, Ling, Ling, Reeves, Shao, Vabrik, Wang   +13 more
core   +1 more source

Ambident Reactivity in the Phenyl + NO Radical Recombination

Chemistry – A European Journal, EarlyView.
ABSTRACT The recombination reaction of nitric oxide (NO) with radicals via its oxygen atom, rather than the more common nitrogen site, offers an intriguing pathway to the formation of oxynitrenes. The photochemical isomerization of nitroso compounds into their corresponding oxynitrenes may involve such a step.
Virinder Bhagat, Adrián Portela‐González, André K. Eckhardt, J. Philipp Wagner   +3 more
wiley   +1 more source

Functionalized 1,3,5-triazine-derivatives as promising anticancer agents: synthesis and cytotoxic activity in vitro

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Introduction. A promising area of application of 1,3,5-triazines in medical chemistry is the development of highly effective anticancer agents. It is noteworthy that a significant cytotoxic effect may occur with 2,4,6-substituted 1,3,5-triazine ...
A. V. Protas, O. V. Mikolaichuk, E. A. Popova, K. V. Timoshchuk, D. N. Maistrenko, O. E. Molchanov, V. V. Sharoyko, K. N. Semenov   +7 more
doaj   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, EarlyView.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine

Compounds
The smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added ...
Partha Sarathi Bera, Yafia Kousin Mirza, Tarunika Sachdeva, Milan Bera   +3 more
doaj   +1 more source

Occupational Asthma and Contact Dermatitis in a Spray Painter after Introduction of an Aziridine Cross-Linker. [PDF]

, 2010
A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to be used in his workplace as a paint activator.
Leffler, C T, Milton, Donald Kirby
core   +1 more source

Chemical modeling for predicting the abundances of certain aldimines and amines in hot cores

, 2021
We consider six isomeric groups (CH3N, CH5N, C2H5N, C2H7N, C3H7N and C3H9N) to review the presence of amines and aldimines within the interstellar medium (ISM). Each of these groups contains at least one aldimine or amine.
Bhat, Bratati, Chakrabarti, Sandip K., Das, Ankan, Etim, Emmanuel E., Gorai, Prasanta, Sil, Milan   +5 more
core   +1 more source