Results 61 to 70 of about 7,765 (231)

Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines

Molecules, 2019
Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals.
Allan Ribeiro da Silva, Deborah Araujo dos Santos, Marcio Weber Paixão, Arlene Gonçalves Corrêa   +3 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Strong Nonradiative Recombination Induced by Pronounced Lone‐Pair Electron Expression Following Deprotonation in Aziridinium Lead Iodide Perovskites

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.
The transition from linear to cyclic organic cations promotes deprotonation and activates VH(N) defects with pronounced lone‐pair electron activity, thereby inducing severe local distortions and highly efficient nonradiative recombination centers. This work unveils a direct structure–defect–performance correlation and proposes design strategies for the
Qingshan Bao, Linyu Bai, Honghe Zhao, Yanting Qin, Xian Zhao, Yanlu Li   +5 more
wiley   +1 more source

Aziridine-2-carboxylic acid derivatives and its open-ring isomers as a novel PDIA1 inhibitors

, 2021
Acyl derivatives of aziridine-2-carboxylic acid have been synthesized and tested as PDIA1 inhibitors. Calculations of charge value and distribution in aziridine ring system and some alkylating agents were performed. For the first time was found that acyl
Kalvins, Ivars, Stojak, Marta, Andrianov, Victor, Kazhoka-Lapsa, Iveta, Chłopicki, Stefan, Zelencova-Gopejenko, Diana, Domracheva, Ilona, Leite, Irena, Loza, Einars   +8 more
core   +1 more source

Recent Studies of (+)-3-Carene Transformations with the Retention of the Native Framework

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2019
This review presents last decade and some past especially relevant studies in the field of (+)-3-carene synthetic transformations. This paper discusses exclusively the transformations of (+)-3-carene, proceeding with the retention of the native bicyclic ...
Serghei Curlat
doaj   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Zinc Tetrafluoroborate-Mediated Ring Expansion of trans-Aziridine-2-carboxylates to cis-2-Iminothiazolidines and cis-Thiazolidine-2-iminium Tetrafluoroborates and Evaluation of Antimicrobial Activity

Cis-2-iminothiazolidines and cis-thiazolidine-2-iminium tetrafluoroborates were successfully produced from trans-N-alkyl aziridine-2-carboxylates and phenyl/alkyl isothiocyanates mediated by zinc tetrafluoroborate in refluxing DCE.
Chayma Ben Maamer (11261033), Emmanuel Vrancken (1991920), Malek Lahmar (16800437), Rihab Dridi (16800434), Mariem Jobran (16800440), Sami Sahtel (16800443), Mohamed Faouzi Zid (11910083), Hadda Imene Ouzari (16800446), Mohamed Ali Tabarki (5607611), Rafâa Besbes (8630496)   +9 more
core   +2 more sources

Aziridinierung eines einzelnen Kohlenstoffatoms in Alkenen mittels Energietransferkatalyse

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
Im Gegensatz zur traditionellen Alken‐Aziridinierung über (formalen) Nitren‐Transfer berichten wir hier über eine Strategie zur intermolekularen Aziridinierung eines einzelnen Alken‐Kohlenstoffatoms bei zusätzlicher Funktionalisierung der anderen Position. Durch Energietransfer‐ (EnT‐)Katalyse werden Alkenylboronate und ‐silane in reaktive Intermediate
Fritz Paulus, Corinna Heusel, Felix H. Wessels, Bünyamin Sikora, Maik G. Niedziella, Kilian van der Beck, Constantin G. Daniliuc, Frank Glorius   +7 more
wiley   +1 more source

Asymmetric Syntheses of Aziridine-2-carboxylates via Reductive Kinetic Resolution of 2H-Azirines

Enantioenriched aziridine-2-carboxylates are valuable organic compounds thanks to their versatility as chiral building blocks. Several syntheses of bioactive molecules employ aziridine-2-carboxylates as a crucial synthetic intermediate, e.g.
Antonio, Rizzo, Yinuo, Zheng, Pauline, Chiu   +2 more
core   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source