Results 81 to 90 of about 7,765 (231)
ChemistryEurope, Volume 4, Issue 6, June 2026.A structurally diverse series of 1‐amino‐izidine scaffolds was accessed through a cascade process combining rhodium‐catalyzed nitrene‐transfer oxyamidation with subsequent nucleophilic cyclization under acidic conditions, proceeding via an in situ generated iminium intermediate.
Grégory Jestin +5 more
wiley +1 more source
A New Self-Polymerization of Acrylic Acid with a Mono-aziridine Containing Compound
, 2013 A new self-polymerization took place between acrylic acid (AA) and a mono-aziridine containing compound, e.g. methyl 3-(aziridin-1-yl) propanoate (MAP) upon mixing that resulted in formation of a linear polyethyleneimine (PEI) with amino-ester bonds ...
Chen, Kan-Nan +1 more
core +1 more source
IUBMB Life, Volume 78, Issue 6, June 2026.ABSTRACT Structure‐based design of covalent drugs has achieved tremendous success by understanding and leveraging the three‐dimensional interactions between small‐molecule drug candidates and their protein targets. However, this approach traditionally relies on high‐resolution co‐complex structures obtained by X‐ray crystallography, NMR, or cryo‐EM ...
Sungwon Jung +2 more
wiley +1 more source
Catalytic approaches towards heterocyclic aziridine and aryl ethylamine scaffolds [PDF]
Nitrogen-containing heterocyclic scaffolds are prevalent within bioactive molecules and natural products. Of these, aziridine scaffolds represent viable targets, both as bioactive molecules (e.g., as covalent inhibitors) but also as synthetic ...
Hilton, Timothy Alex
core +1 more source
Alkylative Ring-Opening of Bicyclic Aziridinium Ion and Its Application for Alkaloid Synthesis
Frontiers in Chemistry, 2019 Alkylative ring-opening of bicyclic aziridinium ion generated from 4-hydroxybutylaziridine with organocopper reagent was achieved successfully to afford 2-alkylsubstituted piperidine in high or moderate yield.
Nagendra Nath Yadav +3 more
doaj +1 more source
Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis
ChemistryOpen, Volume 15, Issue 6, June 2026.This review highlights synthetic advances (2013–2025) in intramolecular C─N bond formation for constructing the pharmaceutically relevant pyrrolidine core. The review is organized into five methodological clusters: 1) intramolecular alkene/alkyne amination; 2) tandem annulations, which involve C─N bond formation as the key step; 3) nucleophilic ...
Rasma Kroņkalne, Māris Turks
wiley +1 more source
Solid phase synthesis of aziridine 2-carboxylates
, 1999 Several oligopeptides and amino acids containing an aziridine 2-carboxylate group were prepared using a solid phase version of the Gabriel-Cromwell reaction.
Filigheddu, S. N. +2 more
core +1 more source
Advances in the Different Synthetic Routes of Fluorinated Hydrazines
The Chemical Record, Volume 26, Issue 6, June 2026.This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
wiley +1 more source
Organocatalyzed enantioselective desymmetrization of aziridines and epoxides
Beilstein Journal of Organic Chemistry, 2013 Enantioselective desymmetrization of meso-aziridines and meso-epoxides with various nucleophiles by organocatalysis has emerged as a cutting-edge approach in recent years.
Ping-An Wang
doaj +1 more source
Progress of Enantioselective Nitrile Biotransformations in Organic Synthesis
CHIMIA, 2009 Recent progress of enantioselective biotransformations of nitriles including various functionalized nitriles, ?-hydroxy and ?-amino nitriles, oxirane- and aziridine-containing carbonitriles is summarized in this short review article.
Mei-Xiang Wang
doaj +1 more source