Advances in the Different Synthetic Routes of Fluorinated Hydrazines
The Chemical Record, EarlyView.This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
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Preparation and ring-opening reactions of N-diphenylphosphinyl vinyl aziridines [PDF]
, 2013 Predominantly (E)-N-diphenylphosphinyl vinyl aziridines are prepared by a reaction of N-diphenylphosphinyl imines with α-bromoallyllithium in the presence of freshly fused ZnCl2. These aziridines undergo a ring-opening reaction with a variety of carbon
Jarvis, Ashley N. +3 more
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Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
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Chiral Brønsted Acid-Catalyzed Asymmetric Synthesis of N-Aryl-cis-aziridine Carboxylate Esters [PDF]
, 2017 We report a multi-component asymmetric Brønsted acid-catalyzed aza-Darzens reaction which is not limited to specific aromatic or heterocyclic aldehydes.
Akiyama +36 more
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Cooperative chalcogen bonding interactions in confined sites activate aziridines [PDF]
, 2022 Haofu Zhu, Panpan Zhou, Yao Wang
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Mechanistic Insights into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C-H Activation. [PDF]
, 2015 Detailed kinetic studies and computational investigations have been performed to elucidate the mechanism of a palladium-catalyzed C-H activation aziridination.
Gaunt, Matthew J, Smalley, Adam P
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Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative
European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.The synthesis of a methylene‐linked acyldepsipeptide (ADEP) is reported. Success relied upon an improve method to generate a versatile vinyl glycine methyl ester synthon and a rationally optimized Grubb’s metathesis. NMR and in silico studies revealed an unusual trans–trans proline orientation for this new unnatural ADEP analog, advancing the ...
Katelyn G. Stevens-Davis +6 more
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Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone [PDF]
, 2011 An efficient and straightforward approach towards the synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone via imination, alpha-chlorination, hydride reduction and ring closure was developed.
D'hooghe, Matthias +6 more
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A Study on the Biological Activity of Optically Pure Aziridine Phosphines and Phosphine Oxides
MoleculesA series of optically pure aziridine phosphines and their corresponding phosphine oxides were synthesized through established chemical methodologies. The compounds were systematically investigated for their biological properties. Notably, all synthesized
Aleksandra Kowalczyk +4 more
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Beilstein Journal of Organic Chemistry, 2011 A novel synthetic methodology has been developed for the synthesis of diethyl 5-alkyl/aryl/heteroaryl substituted 3,4-dihydro-2H-pyrrole-4,4-dicarboxylates (also called 2-substituted pyrroline-4,5-dihydro-3,3-dicarboxylic acid diethyl esters) by iodide ...
Satish S. More +4 more
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